Inflammatory Myofibroblastic Tumor
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor with ALK/TPM3 fusion presenting as ileocolic intussusception: an unusual presentation of an unusual neoplasm.
|
16360423 |
2006 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor with thrombocytosis and a unique chromosomal translocation With ALK rearrangement.
|
16831032 |
2006 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor of the lung in children: anaplastic lymphoma kinase (ALK) expression and clinico-pathological correlation.
|
22280150 |
2012 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor with RANBP2 and ALK gene rearrangement: a report of two cases and literature review.
|
24034896 |
2013 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Inflammatory myofibroblastic tumour of the urinary bladder: the role of immunoglobulin G4 and the comparison of two immunohistochemical antibodies and fluorescence in-situ hybridization for the detection of anaplastic lymphoma kinase alterations.
|
25406945 |
2015 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor has ALK gene rearrangements and is considered a neoplasm as opposed to PCG, which is a reactive polyclonal plasma cell proliferation.
|
30040458 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor (IMT) is a rare benign cancer that can express a more aggressive phenotype related to the genetic mutation of the anaplastic lymphoma kinase receptor (ALK).
|
30900517 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family?
|
11284039 |
2001 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK positivity was observed in 17 of 47 IMTs (36%) and p80 positivity in 16 of 47 IMTs (34%).
|
11406658 |
2001 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK represents one of few examples of a receptor tyrosine kinase implicated in oncogenesis in both haematopoietic and non-haematopoietic tumors, given that ALK fusions also occur in the mesenchymal tumor known as inflammatory myofibroblastic tumor (IMT).
|
15583856 |
2004 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK and cytokeratin, when positive, can be helpful in differentiating IMT from LGMS.
|
18400254 |
2008 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
|
22664824 |
2012 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Anaplastic lymphoma kinase (ALK) gene rearrangements, most often resulting in the tropomyosin 3 (TPM3)-ALK fusion gene, are the main causes of IMT.
|
25596129 |
2015 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK-Positive Inflammatory Myofibroblastic Tumor of the Nipple During Pregnancy-An Unusual Presentation of a Rare Disease.
|
25772857 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, as a consequence of fusion with other oncogenes (NPM, EML4, TIM, etc) or gene amplification, mutation or protein overexpression.
|
29455642 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Anaplastic lymphoma kinase-negative uterine inflammatory myofibroblastic tumor containing the ETV6-NTRK3 fusion gene: a case report.
|
29900760 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
ALK is a receptor tyrosine kinase, associated with many tumor types as diverse as anaplastic large cell lymphomas, inflammatory myofibroblastic tumors, breast and renal cell carcinomas, non-small cell lung cancer, neuroblastomas, and more.
|
30813562 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
A molecular-targeted drug (anaplastic lymphoma kinase inhibitor) was found to be extremely effective as selective therapy for inflammatory myofibroblastic tumor with anaplastic lymphoma kinase translocation.
|
31615346 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
A recent study identified rearrangements of ROS1 (another tyrosine kinase receptor) in a subset of ALK-negative inflammatory myofibroblastic tumors.
|
25612511 |
2015 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Aberrant ALK fusion proteins were also generated in inflammatory fibrosarcoma and a subset of non-small-cell lung cancers, and these proteins are implicated in their pathogenesis.
|
22249260 |
2012 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All 14 IMTs were confirmed to harbor ALK genetic fusion by RNA sequencing, and ALK immunostaining in the form of granular cytoplasmic positivity with paranuclear accentuation was observed in all 14 cases.
|
30015720 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although a similar CLTC-ALK aberration was previously identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic tumor, its association with ALK-positive LBCL seems to be specific and intriguing.
|
12750159 |
2003 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features.
|
18701132 |
2008 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
An inflammatory myofibroblastic tumour of the breast with ALK overexpression.
|
23386486 |
2013 |