ALK, ALK receptor tyrosine kinase, 238

N. diseases: 519; N. variants: 41
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE The autopsied lung tumors harbored ALK G1202R (c. 3604 G>A) and the right renal metastasis harbored ALK G1202R (c. 3604 G>C); the mutation thus comprised different codon changes. 31374369 2019
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 AlteredExpression group BEFREE Herein, we newly identified that truncated form of CHL1 is produced and released from lung tumor tissue in a mouse model expressing human EML4-ALK fusion gene. 29775614 2018
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE Most anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung tumors initially respond to small-molecule ALK inhibitors, but drug resistance often develops. 29505033 2018
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE The lung tumor cells were subjected to fluorescent in situ hybridization and highly sensitive immunohistochemical staining for the ALK protein, both of which produced positive results. 28093881 2017
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE Analysis of ALK translocations in the primary lung tumor would be suitable for planning the use of a TKI for advanced NSCLC, but it would be better to detect metastasis specimens as ALK negative specimens if both primary and metastatic specimens have developed. 29312572 2017
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE These studies may guide the development of comprehensive treatment strategies that take into consideration the various approaches ALK-positive lung tumors use to withstand therapeutic insult. 26719536 2016
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE We found that lung tumors containing ALK rearrangements induced an immunosuppressive microenvironment, regulating the expression of PD-L1 on the surface of lung tumor cells. 26419961 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE CCR 20th Anniversary Commentary: Molecular Pathology of ALK-Rearranged Lung Tumors. 26626570 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE We observed enrichment of gene signatures associated with several resistance drivers (including P2Y receptors) in crizotinib-resistant ALK-rearranged lung tumors compared to treatment-naive controls, supporting a role for these identified mechanisms in clinical ALK inhibitor resistance. 25759024 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE We apply TRUP to RNA-seq data of different tumor types, and find it to be more sensitive than alternative tools in detecting chimeric transcripts, such as secondary rearrangements in EML4-ALK-positive lung tumors, or recurrent inactivating rearrangements affecting RASSF8. 25650807 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE The novel 1A4 antibody represents a promising candidate for screening lung tumors for the presence of ALK rearrangements. 25789835 2015
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE ALK translocation, occurring at a frequency of 6.8% in Chinese patients, defines a unique molecular subgroup of lung tumors. 24775606 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE A comparison of immunohistochemical assays and FISH in detecting the ALK translocation in diagnostic histological and cytological lung tumor material. 24787965 2014
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE A subgroup of anaplastic lymphoma kinase (ALK)-rearranged lung tumours can respond to ALK inhibitors. 22735679 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE Immunohistochemistry has been proposed as a specific and sensitive method to identify EGFR mutations or ALK rearrangements in lung tumours. 22100693 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. 22412972 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE EML4-ALK adenocarcinomas constitute a new molecular subgroup of lung tumours that respond very well to crizotinib, an ALK inhibitor. 22153831 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group BEFREE Using specific and sensitive IHC assays, we analyzed the expression of anaplastic lymphoma kinase (ALK), EGFR L858R, and EGFR E746-A750del mutations in a subset of lung tumors, including those expressing ROS1. 22661537 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE In this article we review the potential role that ALK may have in lung tumor origin, the methodology to detect the different molecular alterations, and the most important clinical aspects of ALK alterations in NSCLC patients. 22584871 2012
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group BEFREE The inhibition of ALK in lung tumors with the ALK rearrangement resulted in tumor shrinkage or stable disease in most patients. 20979469 2010
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group LHGDN Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. 18451166 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group LHGDN EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. 18166835 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 Biomarker group LHGDN EML4-ALK fusion lung cancer: a rare acquired event. 18320074 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 GeneticVariation group LHGDN Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. 18593892 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.100 AlteredExpression group LHGDN EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. 18594010 2008