|
Influenza
|
0.310 |
Biomarker
|
disease |
BEFREE |
Chickens Expressing IFIT5 Ameliorate Clinical Outcome and Pathology of Highly Pathogenic Avian Influenza and Velogenic Newcastle Disease Viruses.
|
30271403 |
2018 |
|
Influenza
|
0.310 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Altogether, this study unveils a prometastatic role of the IFNγ pathway via a new mechanism of action, which raises concerns about its clinical application.<b>Significance:</b> A unique IFIT5-XRN1 complex involved in the turnover of specific tumor suppressive microRNAs is the underlying mechanism of IFNγ-induced epithelial-to-mesenchymal transition in prostate cancer.<i>See related commentary by Liu and Gao, p. 1032</i>.
|
30504123 |
2019 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Altogether, this study unveils a prometastatic role of the IFNγ pathway via a new mechanism of action, which raises concerns about its clinical application.<b>Significance:</b> A unique IFIT5-XRN1 complex involved in the turnover of specific tumor suppressive microRNAs is the underlying mechanism of IFNγ-induced epithelial-to-mesenchymal transition in prostate cancer.<i>See related commentary by Liu and Gao, p. 1032</i>.
|
30504123 |
2019 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings unveil a new IFNγ-STAT1-IFIT5-miRNA-EMT pathway in prostate cancer progression.
|
30877097 |
2019 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings unveil a new IFNγ-STAT1-IFIT5-miRNA-EMT pathway in prostate cancer progression.
|
30877097 |
2019 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Altogether, this study unveils a prometastatic role of the IFNγ pathway via a new mechanism of action, which raises concerns about its clinical application.<b>Significance:</b> A unique IFIT5-XRN1 complex involved in the turnover of specific tumor suppressive microRNAs is the underlying mechanism of IFNγ-induced epithelial-to-mesenchymal transition in prostate cancer.<i>See related commentary by Liu and Gao, p. 1032</i>.
|
30504123 |
2019 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The modulatory networks of NF-κB/RelA in the context epithelial-mesenchymal transition (EMT) and burn injury have different modulators, including those involved in extracellular matrix (FBN1), cytoskeletal regulation (ACTN1), and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long intergenic nonprotein coding RNA, and tumor suppression (FOXP1) for EMT, and TXNIP, GAPDH, PKM2, IFIT5, LDHA, NID1, and TPP1 for burn injury.
|
25844669 |
2015 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, we conclude that IFIT5 is a new oncogene in BCa.
|
31164632 |
2019 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, we conclude that IFIT5 is a new oncogene in BCa.
|
31164632 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of IFIT5 decreased IFNγ-induced cell invasiveness <i>in vitro</i> and lung metastasis <i>in vivo</i>.
|
30504123 |
2019 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, we conclude that IFIT5 is a new oncogene in BCa.
|
31164632 |
2019 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data therefore indicate that p58 is not a single homogenously phosphorylated protein species but rather a population of various phosphoisoforms, with high variability between genotypes.<b>IMPORTANCE</b> Hepatitis C virus infections affect 71 million people worldwide and cause severe chronic liver disease.
|
30258001 |
2018 |
|
Marek Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional analysis of gene expression in CEFs demonstrated that all TLR ligand treatments and MDV infection significantly increased the expression of type I interferons, interleukin (IL)-1β, interferon regulatory factor 7 (IRF7), interferon induced protein with tetratricopeptide repeats 5 (IFIT5), and myxoma-resistance protein (Mx).
|
29570417 |
2018 |
|
Myxoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcriptional analysis of gene expression in CEFs demonstrated that all TLR ligand treatments and MDV infection significantly increased the expression of type I interferons, interleukin (IL)-1β, interferon regulatory factor 7 (IRF7), interferon induced protein with tetratricopeptide repeats 5 (IFIT5), and myxoma-resistance protein (Mx).
|
29570417 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that NO-induced cytostasis in breast cancer cells was due to PKR activation and increased phosphorylation of eIF2-alpha, whereas the reduced susceptibility of normal mammary epithelial cells to NO could be due to the inaccessibility of PKR, which is bound to inhibitor p58.
|
18559534 |
2008 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that NO-induced cytostasis in breast cancer cells was due to PKR activation and increased phosphorylation of eIF2-alpha, whereas the reduced susceptibility of normal mammary epithelial cells to NO could be due to the inaccessibility of PKR, which is bound to inhibitor p58.
|
18559534 |
2008 |