|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
There have been successful examples of targeted therapy improving the outcome of some childhood cancers, such as the addition of an ABL class tyrosine kinase inhibitor to conventional chemotherapy substantially improving the cure rate for patients with BCR-ABL1 positive acute lymphoblastic leukemia.
|
31563145 |
2020 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our B-ALL fluorescence in situ hybridization (FISH) panel confirmed the BCR/ABL1 fusion and monosomies consistent with chromosome studies in approximately 95% of interphase nuclei.
|
30790375 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia.
|
30675008 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
At current work, the combination of sensors were used to detect the presence of BCR-ABL1 as a mutant gene and CEA as a biomarkers of cancer, such a capability makes the package liable for early and certain detection of acute lymphoblastic leukemia.
|
31295447 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Identification and characterization of a murine model of BCR‑ABL1+ acute B‑lymphoblastic leukemia with central nervous system metastasis.
|
31173268 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The ETV6-ABL1 fusion is a rare genetic aberration classified as Philadelphia chromosome-like high-risk B-cell precursor acute lymphoblastic leukemia.
|
30028819 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Four patients presented with B-lymphoblastic leukemia (B-ALL), and of them, two patients with t(8;9)(p22;p24.1) were proven to be B-lymphoblastic crisis of MPN; and the other two cases with t(9p24;v) both were de novo B-ALL, BCR-ABL1-like (Ph-like).
|
30401948 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia.
|
30546081 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A Cryptic NUP214-ABL1 Fusion in B-cell Precursor Acute Lymphoblastic Leukemia.
|
29219890 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.
|
28579617 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of the Immune Checkpoint Modulator OX40 in Acute Lymphoblastic Leukemia Is Associated with BCR-ABL Positivity.
|
30300827 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
ETV6-ABL1 fusion combined with monosomy 7 in childhood B-precursor acute lymphoblastic leukemia.
|
29177615 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Two novel fusion genes, AIF1L-ETV6 and ABL1-AIF1L, result together with ETV6-ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin.
|
29726059 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Successful Use of Nilotinib in the Therapy of a Patient with a Chemoresistant Relapse of BCR-ABL1-Like Phenotype Acute Lymphoblastic Leukemia.
|
30121665 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interphase FISH for BCR-ABL1 rearrangement on neutrophils: A decisive tool to discriminate a lymphoid blast crisis of chronic myeloid leukemia from a de novo BCR-ABL1 positive acute lymphoblastic leukemia.
|
28444777 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy.
|
29434963 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid.
|
28451802 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The introduction of the tyrosine kinase inhibitors (TKI) into the treatment of patients with Ph or BCR-ABL1-positive acute lymphoblastic leukemia has revolutionized the treatment of this poor prognosis acute leukemia.
|
28581459 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Phase II study of imatinib-based chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia.
|
28103625 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
All but one of the cases of ETV6-ABL1 acute lymphoblastic leukemia were classified as BCR-ABL1-like by a standardized assay.
|
27229714 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Firstly, we detected that IK6 existed in 20 of 42 (47.6%) adult BCR-ABL1-positive B-lineage acute lymphoblastic leukemia (BCR-ABL1-positive B-ALL) by using reverse transcribed polymerase chain reaction (PCR) and nucleotide sequencing.
|
27447561 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia.
|
27821800 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
IKZF1 deletions were associated with B-cell precursor acute lymphoblastic leukemia (P=0.036), BCR-ABL1-positive acute lymphoblastic leukemia (P<0.001), and higher white blood cell counts (P=0.005).
|
25261097 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
We performed a comprehensive analysis of the impact of IKZF1(del) in a large cohort of children (n=1223) with BCR-ABL1-negative BCP-ALL treated in the EORTC-CLG trial 58951.
|
26050650 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.
|
26321221 |
2015 |