Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> Compared to controls, SZ subjects had nonsignificant trends toward a decrease in vGLUT1, and an increase in both vGLUT2 and GAD67. vGLUT1 was negatively correlated with GAD67 in normal controls (NCs) and positively correlated in SZ subjects.
|
31062628 |
2019 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
(i) In animal models, NMDAR antagonists reduce parvalbumin and GAD67, as found in schizophrenia.
|
18395805 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Schizophrenia subjects showed significant decreases in mRNA levels of GAD(67), GAD(65), GAT-1, mGluR2, and neuronal nitric oxide synthase.
|
18923069 |
2008 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Schizophrenia subjects showed significant decreases in mRNA levels of GAD(67), GAD(65), GAT-1, mGluR2, and neuronal nitric oxide synthase.
|
18923069 |
2008 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons.
|
25364290 |
2014 |
Schizophrenia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia.
|
17726539 |
2007 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GAD67 and Zif268 mRNA levels were significantly lower and were positively correlated in the schizophrenia subjects.
|
24874453 |
2014 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GAD1 is expressed as both GAD67 and GAD25 mRNA transcripts with the former reported to have a lower expression level in schizophrenia compared to healthy controls and latter was reported to be predominantly expressed fetally, suggesting a role in developmental process.
|
28122016 |
2017 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A recent report suggests that the down-regulation of reelin and glutamic acid decarboxylase (GAD(67)) mRNAs represents 2 of the more consistent findings thus far described in post-mortem material from schizophrenia (SZ) patients [reviewed in.
|
16574235 |
2006 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Alterations in schizophrenia included decreased GAD1 expression and H3K4-trimethylation, predominantly in females and in conjunction with a risk haplotype at the 5' end of GAD1.
|
17942719 |
2007 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Alterations in schizophrenia included decreased GAD1 expression and H3K4-trimethylation, predominantly in females and in conjunction with a risk haplotype at the 5' end of GAD1.
|
17942719 |
2007 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alterations in inhibitory (GABA) neurons, including deficiencies in the GABA synthesizing enzyme GAD67, in the prefrontal cortex in schizophrenia are pronounced in the subpopulations of neurons that contain the calcium-binding protein parvalbumin or the neuropeptide somatostatin.
|
25464914 |
2015 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Alternative splicing of GAD1 and epigenetic state appear to play roles in the developmental profile of GAD1 expression and may contribute to GABA dysfunction in the PFC and hippocampus of patients with schizophrenia.
|
28485403 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although our results are negative, this was the first study to investigate GAD genes in schizophrenia, and further studies of these genes, particularly with schizophrenia subtypes, may prove valuable.
|
15091314 |
2004 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Although the levels of GAD65 and GAD67 messages were increased in schizophrenia subjects, the proportion of the two GAD isoforms remained constant in controls and schizophrenics.
|
15114630 |
2004 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although the levels of GAD65 and GAD67 messages were increased in schizophrenia subjects, the proportion of the two GAD isoforms remained constant in controls and schizophrenics.
|
15114630 |
2004 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Analysis of the effect of medication in the schizophrenia subjects revealed significantly higher expression of GABA-Aα1-3, GABA-Aβ2, GABA-Aγ2, and GAD67 in the medicated group compared to the unmedicated group.
|
25660468 |
2015 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Association of aberrant neural synchrony and altered GAD67 expression following exposure to maternal immune activation, a risk factor for schizophrenia.
|
25072323 |
2014 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia.
|
16513879 |
2006 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia.
|
23864674 |
2013 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population.
|
17303389 |
2007 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cortical interneurons differentiated from induced pluripotent stem cells (iPSCs) of schizophrenia subjects showed significantly lower levels of glutamate decarboxylase 67 (GAD67), replicating findings from multiple postmortem studies, as well as reduced levels of synaptic proteins gehpyrin and NLGN2.
|
31780643 |
2019 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
For GAD(67) mRNA-containing neurons that co-expressed NR(2A)mRNA, their numerical density was decreased by 73% and 52%, in layers 2 and 5, respectively, in subjects with schizophrenia and by 60% in layer 2 in those with bipolar disorder.
|
15237077 |
2004 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, simultaneous detection of PV and GAD67 mRNAs revealed that in subjects with schizophrenia only 55% of PV mRNA-positive neurons had detectable levels of GAD67 mRNA.
|
12867516 |
2003 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GABAergic dysfunction and expression of GAD1 have been implicated in the pathophysiology of schizophrenia, and in working memory impairment.
|
26822489 |
2016 |