GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 Biomarker disease BEFREE The present work focuses on the early stage of disease progression and uses TgF344-AD rats that recapitulate a broad repertoire of AD-like pathologies to investigate the neuronal network functioning using simultaneous intracranial recordings from the hippocampus (HPC) and the medial prefrontal cortex (mPFC), followed by pathological analyses of gamma-aminobutyric acid (GABA<sub>A</sub> ) receptor subunits α1<sub>,</sub> α5, and δ, and glutamic acid decarboxylases (GAD65 and GAD67). 28777881 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 AlteredExpression disease BEFREE In the present study, we used a non-transgenic rat model of AD obtained by intracerebroventricular streptozocin (STZ) injection and assessed the effects of muscimol and baclofen at very low doses (0.01-0.05mg/kg) on spatial memory and the expression of cortical and hippocampal proteins related to neuroinflammation, namely proteins involved in astroglial functions (glial fibrillary acidic protein, GFAP), GABA synthesis (GABA synthesizing enzyme, glutamic acid decarboxylase 67, GAD67) and acetylcholine degradation (acetylcholine esterase). 29133125 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 Biomarker disease BEFREE To genetically reduce GAD67 in AD mouse brains, we crossed the Gad67 haploinsufficient mice (GAD67-GFP<sup>+/-</sup>) with 5xFAD mice (harboring 5 human familial AD mutations in APP and PS1 genes) to generate a new line of bigenic mice. 29017573 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.040 AlteredExpression disease BEFREE The expression of GAD67 mRNA per neuron was similar in AD and control subjects both in the dorsal and ventral striatum. 9681468 1998