GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET An association between the reduced levels of SLC1A2 and GAD1 in the dorsolateral prefrontal cortex in major depressive disorder: possible involvement of an attenuated RAF/MEK/ERK signaling pathway. 24652383 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 AlteredExpression disease BEFREE An association between the reduced levels of SLC1A2 and GAD1 in the dorsolateral prefrontal cortex in major depressive disorder: possible involvement of an attenuated RAF/MEK/ERK signaling pathway. 24652383 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders. 21226980 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET Individuals with major depression also expressed significantly less GAD67 mRNA (44%) compared with controls in CA4 of the hippocampus. 21223646 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression. 16718280 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET We report findings based on analyses of self-reports of six common adolescent psychopathologies (attention deficit/hyperactivity disorder, ADHD; conduct disorder, CD; oppositional defiant disorder, ODD; generalized anxiety disorder, GAD; separation anxiety disorder, SAD; and major depressive disorder, MDD) in a sample of 1,162 male and female adolescent (12-19 years) twin pairs and 426 siblings. 16465480 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 GeneticVariation disease BEFREE Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression. 16718280 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 GeneticVariation disease BEFREE We screened all the 17 exons of the GAD67 gene for mutations using single strand conformation polymorphism (SSCP) or denaturing high pressure liquid chromatography (dHPLC) in a sample of 43 individuals diagnosed with major unipolar depression or other disorders with putative GABAergic dysfunction. 14681921 2004