GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 AlteredExpression disease BEFREE This exploratory study provides an initial step for future studies to investigate an association between the reductions in SLC1A2 and GAD1 mRNA expression and their relation to the attenuation of the RAF/MEK/ERK signaling pathway in the dlPFC in MDD. 24652383 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 Biomarker disease PSYGENET This exploratory study provides an initial step for future studies to investigate an association between the reductions in SLC1A2 and GAD1 mRNA expression and their relation to the attenuation of the RAF/MEK/ERK signaling pathway in the dlPFC in MDD. 24652383 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 Biomarker disease PSYGENET Individuals with major depression also expressed significantly less GAD67 mRNA (44%) compared with controls in CA4 of the hippocampus. 21223646 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 Biomarker disease PSYGENET BPD subjects demonstrated significantly reduced PV mRNA, trend level reduction in SST mRNA and no alterations in GAD67, GAD65, or CR mRNA levels; MDD subjects demonstrated reduced SST mRNA expression without alterations in the other transcripts. 21226980 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 Biomarker disease BEFREE We used real-time quantitative polymerase chain reaction (qPCR) to assess expression levels of two GABA synthesizing enzymes (glutamate decarboxylase; GAD65 and GAD67) and of three markers of GABA neuron subpopulations (PV, CR, SST) in the dorsolateral prefrontal cortex (DLPFC; Brodmann area 9) in triads (n=19) of control subjects and matched subjects with BPD or MDD. 21226980 2011
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 Biomarker disease PSYGENET We report findings based on analyses of self-reports of six common adolescent psychopathologies (attention deficit/hyperactivity disorder, ADHD; conduct disorder, CD; oppositional defiant disorder, ODD; generalized anxiety disorder, GAD; separation anxiety disorder, SAD; and major depressive disorder, MDD) in a sample of 1,162 male and female adolescent (12-19 years) twin pairs and 426 siblings. 16465480 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 GeneticVariation disease BEFREE Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression. 16718280 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 Biomarker disease PSYGENET Subject to confirmation in an independent sample, our study suggests that variations in the GAD1 gene may contribute to individual differences in N and impact susceptibility across a range of anxiety disorders and major depression. 16718280 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.530 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005