KLK5, kallikrein related peptidase 5, 25818

N. diseases: 59; N. variants: 0
Disease: Dermatitis, Atopic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.050 GeneticVariation disease BEFREE The inhibitory activities of the LEKTI domain 4 (D4) and D6 WT and AD-associated mutants on the enzyme activities of KLK5 and KLK7 were compared using fluorogenic substrates. 31407378 2020
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.050 AlteredExpression disease BEFREE The expressions of LL-37 and KLK-5 were found to be altered in various dermatoses, including atopic dermatitis, psoriasis, and rosacea. 31465746 2020
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.050 AlteredExpression disease BEFREE Upregulation of KLK5 and abnormal expression of desmoglein 1 (DSG1) and filaggrin, but not PAR2 were identified in AD skin. 28238749 2017
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.050 AlteredExpression disease BEFREE The excessive activation of KLK5 causes an exacerbation of dermatoses, such as rosacea and atopic dermatitis. 29077044 2017
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.050 Biomarker disease BEFREE Our study identifies KLK5 as an important contributor to the NS proteolytic cascade and provides a new and viable model for the evaluation of future targeted therapies for NS or related diseases such as atopic dermatitis. 24534191 2014