KLK5, kallikrein related peptidase 5, 25818

N. diseases: 59; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 Biomarker disease BEFREE The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway. 24158494 2014
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 AlteredExpression disease BEFREE Recently, our group has depicted that KLK4, KLK5, and KLK14 are differentially expressed in breast carcinoma. 23086576 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 Biomarker disease BEFREE To further determine their role and clinical significance in breast cancer and to explore the relationship between KLK5 and KLK7, the mRNA levels of KLK5 and KLK7 in normal breast tissues, benign breast tissues, primary tumors, and lymph node metastases were detected by real-time reverse transcription-polymerase chain reaction and microarray. 19453546 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 AlteredExpression disease BEFREE The steroid hormone receptor-positive breast cancer cell line BT-474 was used to examine the effect of different steroids on the expression levels of KLK5-SV2. 15627884 2005
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 Biomarker disease BEFREE Hormonal regulation experiments suggest that KLK5-SV1 is regulated by steroid hormones in the BT-474 breast cancer cell line. 15361712 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 AlteredExpression disease BEFREE X-profiler comparison of two pools of normal and breast cancer libraries further verified the presence of significant downregulation of expression levels of 4 of the kallikreins genes (KLK5, 6, 10, 12). 14710225 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 AlteredExpression disease BEFREE We studied KLK5 expression in 179 patients with different stages and grades of epithelial breast carcinoma by quantitative reverse transcription-PCR (RT-PCR), using LightCycler((R)) technology. 12142380 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 AlteredExpression disease BEFREE We have previously shown that KLK5 is differentially expressed in ovarian and breast cancer. 11948967 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.090 AlteredExpression disease BEFREE Previous investigations have established that the expression of KLK5 is estrogen and progestin driven in the BT-474 breast cancer cell line. 12385949 2002