GATA2, GATA binding protein 2, 2624

N. diseases: 229; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 GeneticVariation group BEFREE Various heteroallelic GATA2 gene mutations are associated with a variety of hematological neoplasms, including myelodysplastic syndromes and leukemias. 30710465 2019
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 GeneticVariation group BEFREE The absence of deleterious mutations in this large cohort of familial aggregations of hematological malignancies may strengthen the hypothesis that GATA2 mutations are an important predisposing factor, although as a secondary genetic event, required for the development of overt malignant disease. 28752392 2017
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 AlteredExpression group BEFREE GATA binding protein 2 (GATA2) is a transcription factor that has essential roles in hematologic malignancies and progression of various solid tumors. 26287967 2015
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.040 GeneticVariation group BEFREE Hence, we concluded GATA-2 L359 V is exclusively associated with CML progression but not other hematological malignancies and P250A is a new single nucleotide polymorphism. 19304323 2009