GATA4, GATA binding protein 4, 2626

N. diseases: 336; N. variants: 72
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 Biomarker disease BEFREE Bone marrow mesenchymal stem cells overexpressing GATA-4 improve cardiac function following myocardial infarction. 31090492 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 AlteredExpression disease BEFREE Exercise training at different intensities improved cardiac function and levels of stem cell and cardiomyocyte markers, and reduced infarct size. mRNA levels of GATA4, Nkx2.5 and c-Kit and protein expression of Nkx2.5 and c-Kit were significantly increased in all MI-exercise groups. 30802510 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 Biomarker disease BEFREE Injection of GATA-4-BMSC exosomes in mice 48 h after MI increased cardiac function over the next 96 h; increased cardiac blood vessel density and number of c-kit-positive cells and decreased apoptotic cardiomyocyte cells were also observed. 29899566 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 Biomarker disease BEFREE These results indicate significant potential for small molecules targeting GATA4-NKX2-5 interaction to promote myocardial repair after myocardial infarction and other cardiac injuries. 29545582 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 AlteredExpression disease BEFREE Using NOD-SCID murine model of MI and human skeletal myoblast transplantation we were able to show that SkMC administration significantly affected gene expression profile (p<0.05) (NPPB, CTGF, GATA4, SERCA2a, PLB) of the heart ventricular tissue and this change was beneficial for the heart function. 26457413 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 Therapeutic disease RGD Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. 23948075 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.550 Therapeutic disease CTD_human Myocardial infarction, caused by ligating the left anterior descending coronary artery, significantly decreased the DNA binding activity of GATA-4 at day 1, whereas at 2 weeks the GATA-4 DNA binding was significantly upregulated. 20200331 2010