GCK, glucokinase, 2645

N. diseases: 210; N. variants: 182
Disease: Fatty Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.220 AlteredExpression disease BEFREE The up-regulation of expression of hepatic genes related to liver steatosis (CPT1A, FASN, LEPR, RXRA, IGFBP1, PPARGC1A and SLC2A4) was detected in our rhesus model, as was the down-regulation of such genes (CYP7A1, HMGCR, GCK and PNPLA3) and the up-regulation of expression of hepatic genes related to liver cancer (E2F1, OPCML, FZD7, IGFBP1 and LEF1). 26442469 2015
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.220 Biomarker disease RGD Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans. 22925001 2013
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.220 AlteredExpression disease BEFREE This suggests that increased GCK activity may induce fatty liver and its metabolic and hepatic consequences in humans. 21490074 2011