NOX1, NADPH oxidase 1, 27035

N. diseases: 142; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.040 AlteredExpression phenotype BEFREE In colorectal cancer, redox signaling exhibits two Janus faces: On the one hand, NOX1 up-regulation and derived hydrogen peroxide enhance Wnt/β-catenin and Notch proliferating pathways; on the other hand, ROS may disrupt tumor progression through different pro-apoptotic mechanisms. 28062361 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.040 AlteredExpression phenotype BEFREE Gene-neighbour and gene set enrichment analyses revealed that NOX1/2/5 were strongly correlated with genes associated with cancer cell survival and metastasis, whereas increased NOX4 and DUOX1 expression was associated with genes that inhibit tumour progression. 28894215 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.040 Biomarker phenotype BEFREE A catalytic subunit of NADPH oxidase 1 (Nox1) is implicated to be involved in neoplastic progression in human epithelial cancers. 21877197 2011
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.040 Biomarker phenotype BEFREE Here, to further investigate the role of HIPK2 in p53 activation, we started with the finding that HIPK2 inhibition upregulated Nox1, a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase, involved in tumor progression and ROS production. 20171273 2010