Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
We propose that NOX1-dependent mTORC1 activation via S100A9 oxidation in VPS41-/VPS39-positive lysosomes is crucial for colon CSC proliferation and colon cancer progression.
|
31365870 |
2019 |
Malignant tumor of colon
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
These studies imply that NOX1 expression, mediated by IL-4/IL-13, could contribute to an oxidant milieu capable of supporting the initiation or progression of colonic cancer, suggesting a role for NOX1 as a therapeutic target.
|
28498822 |
2017 |
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
These studies suggest a role for NOX1 in maintaining the proliferative phenotype of some colon cancers and the potential of NOX1 as a therapeutic target in this disease.
|
28330872 |
2017 |
Malignant tumor of colon
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Nox1 overexpression promoted colon cancer cell growth, migration, and invasion through the EGFR-PI3K-AKT signaling pathway.
|
27874952 |
2016 |
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells.
|
26781991 |
2016 |
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
We conclude that vinculin and E-cadherin, but not Nox1, may serve as biomarkers for colon cancer progression.
|
23627409 |
2013 |
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings suggest that iodonium analogs have therapeutic potential for NADPH oxidase-containing human colon cancers in vivo and that at least part of their antineoplastic mechanism of action may be related to targeting Nox1.
|
23314043 |
2013 |
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
CTD_human |
In HT29 human colon cancer cells, Nox1 knockdown induced G1 cell cycle arrest, whereas in Caco-2 cells there was a strong apoptotic response, with increased levels of cleaved caspase-3, -6, -7 and poly(ADP-ribose)polymerase.
|
20715105 |
2011 |
Malignant tumor of colon
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Nox1 and Nox4 mRNA and protein levels also were markedly elevated in a panel of primary human colon cancers, compared with their matched controls.
|
20715105 |
2011 |
Malignant tumor of colon
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Herein, we examine the expression of Nox1 mRNA in 24 colon tumors of various stages compared with paired adjacent normal tissue from the same patient, and correlate expression with some common mutations associated with colon cancer.
|
18398843 |
2008 |
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
In the PhIP-induced colon tumors obtained after 1 year, Nox1, Nox4, NFκB-p50 and NFκB-p65 were all highly overexpressed compared with their levels in adjacent normal-looking colonic mucosa.
|
20715105 |
2011 |
Colonic Neoplasms
|
0.310 |
AlteredExpression
|
group |
BEFREE |
Herein, we examine the expression of Nox1 mRNA in 24 colon tumors of various stages compared with paired adjacent normal tissue from the same patient, and correlate expression with some common mutations associated with colon cancer.
|
18398843 |
2008 |
Colonic Neoplasms
|
0.310 |
AlteredExpression
|
group |
LHGDN |
Herein, we examine the expression of Nox1 mRNA in 24 colon tumors of various stages compared with paired adjacent normal tissue from the same patient, and correlate expression with some common mutations associated with colon cancer.
|
18398843 |
2008 |
Heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Hypercholesterolemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Atorvastatin inhibits oxidative stress via adiponectin-mediated NADPH oxidase down-regulation in hypercholesterolemic patients.
|
20832062 |
2010 |
Left-Sided Heart Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Heart Failure, Right-Sided
|
0.300 |
Biomarker
|
disease |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Myocardial Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Heart Decompensation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure.
|
20304815 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Dependence on NOX1 expression or mTOR kinase activity is corroborated in the xenograft tumors and mouse colon cancer-derived organoids.
|
31365870 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously showed that NADPH oxidase organizer 1 (Noxo1), a component of NADPH oxidase 1 (NOX1), is a TNF-α-induced tumor-promoting factor in gastric tumorigenesis.
|
30700829 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
|
30445007 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Notably, genetic and pharmacologic inhibition of NOX1 activity reduced angiogenesis and growth of A549 tumors in mice.
|
29915721 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor cells, in contrast to non-malignant cells, show sustained expression of membrane-associated NADPH oxidase-1 and therefore generate extracellular superoxide anions and their dismutation product H<sub>2</sub>O<sub>2</sub> In order to prevent intercellular reactive oxygen species/reactive nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling, tumor cells need to express membrane-associated catalase that interferes with HOCl and nitric oxide/peroxynitrite signaling.
|
28179303 |
2017 |