NOX1, NADPH oxidase 1, 27035

N. diseases: 142; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 Biomarker disease BEFREE We propose that NOX1-dependent mTORC1 activation via S100A9 oxidation in VPS41-/VPS39-positive lysosomes is crucial for colon CSC proliferation and colon cancer progression. 31365870 2019
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 AlteredExpression disease BEFREE These studies imply that NOX1 expression, mediated by IL-4/IL-13, could contribute to an oxidant milieu capable of supporting the initiation or progression of colonic cancer, suggesting a role for NOX1 as a therapeutic target. 28498822 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 Biomarker disease BEFREE These studies suggest a role for NOX1 in maintaining the proliferative phenotype of some colon cancers and the potential of NOX1 as a therapeutic target in this disease. 28330872 2017
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 AlteredExpression disease BEFREE Nox1 overexpression promoted colon cancer cell growth, migration, and invasion through the EGFR-PI3K-AKT signaling pathway. 27874952 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 Biomarker disease BEFREE NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells. 26781991 2016
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 Biomarker disease BEFREE We conclude that vinculin and E-cadherin, but not Nox1, may serve as biomarkers for colon cancer progression. 23627409 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 Biomarker disease BEFREE These findings suggest that iodonium analogs have therapeutic potential for NADPH oxidase-containing human colon cancers in vivo and that at least part of their antineoplastic mechanism of action may be related to targeting Nox1. 23314043 2013
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 Biomarker disease CTD_human In HT29 human colon cancer cells, Nox1 knockdown induced G1 cell cycle arrest, whereas in Caco-2 cells there was a strong apoptotic response, with increased levels of cleaved caspase-3, -6, -7 and poly(ADP-ribose)polymerase. 20715105 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 AlteredExpression disease BEFREE Nox1 and Nox4 mRNA and protein levels also were markedly elevated in a panel of primary human colon cancers, compared with their matched controls. 20715105 2011
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.390 AlteredExpression disease BEFREE Herein, we examine the expression of Nox1 mRNA in 24 colon tumors of various stages compared with paired adjacent normal tissue from the same patient, and correlate expression with some common mutations associated with colon cancer. 18398843 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.310 Biomarker group CTD_human In the PhIP-induced colon tumors obtained after 1 year, Nox1, Nox4, NFκB-p50 and NFκB-p65 were all highly overexpressed compared with their levels in adjacent normal-looking colonic mucosa. 20715105 2011
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.310 AlteredExpression group BEFREE Herein, we examine the expression of Nox1 mRNA in 24 colon tumors of various stages compared with paired adjacent normal tissue from the same patient, and correlate expression with some common mutations associated with colon cancer. 18398843 2008
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.310 AlteredExpression group LHGDN Herein, we examine the expression of Nox1 mRNA in 24 colon tumors of various stages compared with paired adjacent normal tissue from the same patient, and correlate expression with some common mutations associated with colon cancer. 18398843 2008
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.300 Biomarker disease CTD_human Atorvastatin inhibits oxidative stress via adiponectin-mediated NADPH oxidase down-regulation in hypercholesterolemic patients. 20832062 2010
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure
0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0235527
Disease: Heart Failure, Right-Sided
Heart Failure, Right-Sided
0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C1959583
Disease: Myocardial Failure
Myocardial Failure
0.300 Biomarker disease CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C1961112
Disease: Heart Decompensation
Heart Decompensation
0.300 Biomarker phenotype CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Dependence on NOX1 expression or mTOR kinase activity is corroborated in the xenograft tumors and mouse colon cancer-derived organoids. 31365870 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE We previously showed that NADPH oxidase organizer 1 (Noxo1), a component of NADPH oxidase 1 (NOX1), is a TNF-α-induced tumor-promoting factor in gastric tumorigenesis. 30700829 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. 30445007 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Notably, genetic and pharmacologic inhibition of NOX1 activity reduced angiogenesis and growth of A549 tumors in mice. 29915721 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Tumor cells, in contrast to non-malignant cells, show sustained expression of membrane-associated NADPH oxidase-1 and therefore generate extracellular superoxide anions and their dismutation product H<sub>2</sub>O<sub>2</sub> In order to prevent intercellular reactive oxygen species/reactive nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling, tumor cells need to express membrane-associated catalase that interferes with HOCl and nitric oxide/peroxynitrite signaling. 28179303 2017