NOX1, NADPH oxidase 1, 27035

N. diseases: 142; N. variants: 3
Disease: Idiopathic pulmonary arterial hypertension ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.040 Biomarker disease BEFREE These findings reveal a new signaling pathway by which Nox1 via induction of CREB and Gremlin1 signaling contributes to vascular remodeling and provide preclinical indication of its significance in PAH. 30802716 2019
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.040 AlteredExpression disease BEFREE Findings demonstrate for the first time an up-regulation of NADPH oxidase 1 (Nox1) at the transcript and protein level in resistance vessels from PAH compared with non-PAH patients. 28522681 2017
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.040 Biomarker disease BEFREE Our results suggest that 5-HT<sub>1B</sub> receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in PAH. 28473438 2017
CUI: C3203102
Disease: Idiopathic pulmonary arterial hypertension
Idiopathic pulmonary arterial hypertension 		0.040 AlteredExpression disease BEFREE Basal expression of Nox1/Nox4 was potentiated in PAH-hPASMCs. 27402919 2016