Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the DISC1 gene mutation is linked to schizophrenia and depression.
|
31601402 |
2019 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We aimed to investigate whether DISC1 differentially modulates brain function during executive and memory processing, and morphology in regions relevant for depression and anxiety disorders (affective disorders).
|
25533973 |
2015 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We aimed to investigate whether DISC1 differentially modulates brain function during executive and memory processing, and morphology in regions relevant for depression and anxiety disorders (affective disorders).
|
25533973 |
2015 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We report the novel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk factor for psychiatric illnesses, such as depression and schizophrenia.
|
25224257 |
2015 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Twenty-two human brain imaging studies have examined the influence of DISC1 variants in health, schizophrenia, bipolar disorder or depression.
|
23602339 |
2013 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Overall, we find neurobiological changes accompanying social anhedonia in the NAC of DISC1-Q31L mutant mice, consistent with a role for DISC1 in regulating social reward as an endophenotype of depression.
|
23011268 |
2013 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression.
|
22547224 |
2012 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression.
|
22547224 |
2012 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
PSYGENET |
A recent study reported that N-ethyl-N-nitrosourea (ENU)-induced mutations in exon 2 of the mouse Disc1 gene, which resulted in the amino acid exchange of Q31L and L100P, caused an increase in depression-like behavior in 31 L mutant mice and schizophrenia-like behavior in 100P mutant mice; thus, these are potential animal models of psychiatric disorders.
|
22348257 |
2012 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Disrupted-in-Schizophrenia-1 (DISC1) is a genetic susceptibility locus for major mental illness, including schizophrenia and depression.
|
22832659 |
2011 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cognitive measures of working memory (rs2793094, P=3.38 × 10(-4)), as well as lifetime history of depression (rs4658966, P=4.33 × 10(-4); rs12137417, P=4.93 × 10(-4)) and panic (rs12137417, P=7.41 × 10(-4)) were associated with DISC1 sequence variation.
|
21483430 |
2011 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
|
19255581 |
2010 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data are consistent with: (i) the high frequency of depression in the large Scottish family with a translocation disrupting DISC1; (ii) linkage disequilibrium analysis demonstrating haplotypes associated with relatively small increases in risk for bipolar disorder (<3-fold odds ratio).
|
20850505 |
2010 |
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altered DISC1-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression.
|
17823207 |
2007 |
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that Disc1 missense mutations in mice give rise to phenotypes related to depression and schizophrenia, thus supporting the role of DISC1 in major mental illness.
|
17481393 |
2007 |