ANGPT1, angiopoietin 1, 284

N. diseases: 340; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE The aims of this study were to determine the biological consequences of elevated expression of ΔNp73, an N-terminal truncated isoform of TP73, and to evaluate targeting of its downstream mediators, the angiopoietin 1 (ANGPT1)/tunica interna endothelial cell kinase 2 (Tie2) axis, by using a highly potent, orally available small-molecule inhibitor (rebastinib) in GBM. 31763674 2020
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 GeneticVariation disease BEFREE The Ang-(1-7) was proven to have an inhibitory effect on glioblastoma growth. 30229380 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1. 30924128 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Using two patient-derived novel primary cell culture models (MTA10 and KW10), we developed a minimal but unique four-gene signature comprising genes vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor B (VEGF-B) and angiopoietin 1 (ANG1), angiopoietin 2 (ANG2) that effectively segregated the proneural (MTA10) and mesenchymal (KW10) glioblastoma subtypes. 28744448 2017
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Higher mRNA expression levels of angiogenic factors (vascular endothelial growth factor, angiopoietin 1, platelet-derived growth factor, and insulin-like growth factor) and stromal-derived factor-1 (SDF-1/CXCL12) were observed in AT-MSCs, and highly vascularized tumors were developed when AT-MSCs and GBM were cotransplanted. 23231075 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression disease BEFREE The expression of angiopoietin-1 was higher in ependymomas than in glioblastomas (p = 0.03), whereas angiopoietin-2 expression was similar. 20367336 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease LHGDN Role of Ang1 and its interaction with VEGF-A in astrocytomas. 15453096 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma. 14712484 2004
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 Biomarker disease BEFREE Coculture of glioblastoma cell lines producing Ang1 with endothelium demonstrated a key role of this ligand in the control of EC network organization. 11304469 2001
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.100 AlteredExpression disease BEFREE Whereas Ang-1 mRNA was expressed in tumor cells, Ang-2 mRNA was detected in endothelial cells of a subset of glioblastoma blood vessels. 9811337 1998