Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hence, our studies highlight a new role for the acute phase protein AGP-1 in sepsis via its interaction with TLR-2 signaling mechanisms to selectively promote responsiveness to one of the two major gram-negative endotoxins, contributing to the complicated pathobiology of sepsis.
|
31239174 |
2019 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-1 (Ang-1) is a key regulator of angiogenesis and endothelial activation and has been studied as an objective biomarker in disease states such as atherosclerosis, sepsis, and severe malaria.
|
30865052 |
2019 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The pooled mean differences in biomarker concentration (nonsurvivors - survivors), measured at onset of sepsis, are listed as follows: (1) Ang-1: - 2.9 ng/ml (95% CI - 4.1 to - 1.7, p < 0.01); (2) Ang-2: 4.9 ng/ml (95% CI 2.6 to 7.1, p < 0.01); (3) HMGB1: 1.2 ng/ml (95% CI 0.0 to 2.4, p = 0.05); (4) sRAGE: 1003 pg/ml (95% CI 628 to 1377, p < 0.01); (5) sTREM-1: 87 pg/ml (95% CI 2 to 171, p = 0.04); (6) suPAR: 5.2 ng/ml (95% CI 4.5 to 6.0, p < 0.01).
|
31705327 |
2019 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Four latent factors (Factor 1-4) were identified, each potentially representing distinct biological processes for the endothelial response to sepsis: Factor 1 (CHI3L1, sTREM1, sFLT1); Factor 2 (ANGPT1, PF4, VEGF); Factor 3 (CXCL10, VWF, sICAM1); and Factor 4 (ANGPT2, sTEK).
|
31013257 |
2019 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the effect of Ang-(1-7) on sepsis is unknown, in this study we aimed to determine the impact of Ang-(1-7) on pathophysiologic changes in a clinically relevant model of polymicrobial sepsis induced by cecal ligation and puncture (CLP).
|
30367644 |
2018 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-1 (Ang-1)-mediated Tie2 activation reduces, and the Ang-1 antagonist Ang-2 increases, inflammation and endothelial permeability in sepsis.
|
29132435 |
2017 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns.
|
28538018 |
2017 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MAT.Ang-1 was administered intravenously 20 hours after the onset of sepsis.
|
23036162 |
2012 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In order to reverse the effects of the sepsis-induced suppression of Ang-1 and elevation of Ang-2 we aimed to investigate whether an intravenous injection of recombinant human (rh) Ang-1 protects against MODS in murine sepsis.
|
21531574 |
2011 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We conclude that in vivo endotoxemia triggers functional inhibition of the Ang-1/Tie-2 receptor pathway by reducing Ang-1 and Tie-2 expression and inducing Ang-2 levels and that this response may contribute to enhanced vascular leakage in sepsis.
|
18310225 |
2008 |
Septicemia
|
0.400 |
Therapeutic
|
disease |
CTD_human |
Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis.
|
16005988 |
2005 |