|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The melanin-concentrating hormone receptor 1 (MCHR1) has become an important pharmacological target, since it may be involved in various diseases, such as diabetes, insulin resistance, and obesity.
|
29948643 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review, the current approaches to treat obesity such as the development of diacylglycerol Oacyltransferase- 1 inhibitors, growth hormone secretagogue receptor-1a antagonists/inverse agonists, melanocortin-3 receptors agonists and melanin concentrating hormone receptor-1 antagonists, will be discussed.
|
27320641 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models.
|
27986627 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We also comment on the utility of small-molecule MCHR1 antagonists for the treatment of obesity and affective disorders compared to existing therapies and provide a critical overview of the potential risks.
|
19418262 |
2009 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In previous studies of associations of variants in the genes UCP2, UCP3, PPARG2, CART, GRL, MC4R, MKKS, SHP, GHRL, and MCHR1 with obesity, we have used a case-control approach with cases defined by a threshold for BMI.
|
20054173 |
2008 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) of the MCHR1 gene have been previously associated with obesity, but the results are inconsistent among different populations.
|
18198296 |
2007 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This review details the rising need for new treatments for obesity; the rationale and target validation of MCHR1 receptor antagonists as potential treatments for this disease; and the current status of the numerous small molecule MCHR1 antagonists in development by different companies.
|
17655875 |
2007 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
However, similar associations were found when both adults and children were analyzed together (P = 0.006, 0.783 [0.658-0.930]), suggesting that severe forms of obesity with early onset may be associated with SNPs in MCHR1.
|
16186414 |
2005 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Mutation analysis of the MCHR1 gene in human obesity.
|
15941924 |
2005 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Substituted phenyl biaryl urea derivatives were synthesized and evaluated as MCH-R1 antagonists for the treatment of obesity.
|
16033253 |
2005 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
RGD |
We used real-time PCR to measure the hypothalamic expression of MCH and its receptor (MCHR1) in two contrasting models of altered nutritional status, namely, obesity induced by 8 weeks' voluntary overeating and food restriction for 10 days.
|
15363890 |
2004 |