|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest that the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.European Journal of Human Genetics (2005) 13, 807-814. doi:10.1038/sj.ejhg.5201418 Published online 20 April 2005.
|
15841096 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication.
|
11807413 |
2001 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins.
|
28283559 |
2017 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found decreased NR1 expression in all three illnesses, decreased NR2A in schizophrenia and major depression, and decreased NR2C in schizophrenia.We found no changes of NR2B or NR2D.
|
18033238 |
2008 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we investigated whether expression of this NR2B-associated trafficking complex might be abnormal in schizophrenia.
|
20347576 |
2010 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia.
|
15211626 |
2004 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation in the NR2B gene predicts reduced levels of the obligatory NR1 subunit, suggesting a novel mechanism by which the NR2B SNP may negatively influence other NMDAR subunit expression and reasoning ability in schizophrenia.
|
23070074 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It is necessary to explain the inconsistency of these results and to clarify the contribution of the GRIN2B gene to schizophrenia.
|
17224684 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
GRIN2B variants were genotyped using standard TaqMan procedures in 175 European patients with schizophrenia deemed resistant or intolerant to treatment.
|
26876050 |
2016 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
LHGDN |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The significant associations and interactions were located at the 3' region of GRIN2B suggesting that genetic variation in this part of the gene may be involved in the pathophysiology of schizophrenia.
|
21919190 |
2011 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
It has also been demonstrated that the level of an ionotropic N-methyl-d-aspartate 2B subunit (GRIN2B) of the glutamate receptor tends to increase after subchronic administration of clozapine, suggesting that GRIN2B may play an active role in the pathogenesis of schizophrenia and the function of clozapine medication.
|
11807413 |
2001 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray.
|
15841096 |
2005 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
<i>N</i>-Methyl D-aspartate receptor subtype 2B (NR2B)-containing NMDAR are associated with cognitive dysfunction in schizophrenia.
|
29695955 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variations in the N-methyl-d-aspartate receptor 2B subunit gene (GRIN2B) have been associated with schizophrenia, a psychiatric disorder associated with reduced left-hemispheric language dominance.
|
21827795 |
2011 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia.
|
17669510 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we performed a case-control study to identify polymorphisms of the GRIN2B gene that may confer susceptibility to SZ in the Han Chinese population.
|
26020650 |
2015 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Especially, GluN2B, a subunit of NMDA receptors, associated trafficking complex is altered in the prefrontal cortex of schizophrenia.
|
26421900 |
2015 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we performed western blot analysis to determine whether protein levels of NMDA receptor subunits (NR1, NR2A, NR2B) and associated PSD proteins (NF-L, PSD95, SAP102) are altered in schizophrenia.
|
16762023 |
2006 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To further examine the association between mutations in GRIN2B and SCZ/ASD development, a larger sample size and functional experiments are needed.
|
27616045 |
2016 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
These results suggest that GRIN2B variations might be linked with susceptibility to schizophrenia.
|
15211626 |
2004 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, we found that upon crack inhalation mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A and NR2B NMDA receptor subunits in the PFC.
|
28314129 |
2017 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GRIN2B may be associated with schizophrenia and interaction effects of the polymorphisms in hsa-miR-219, CAKM2G, GRIN2B and GRIN3A may confer susceptibility to schizophrenia in the Chinese Han population.
|
26257337 |
2015 |