Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Especially, GluN2B, a subunit of NMDA receptors, associated trafficking complex is altered in the prefrontal cortex of schizophrenia.
|
26421900 |
2015 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we performed western blot analysis to determine whether protein levels of NMDA receptor subunits (NR1, NR2A, NR2B) and associated PSD proteins (NF-L, PSD95, SAP102) are altered in schizophrenia.
|
16762023 |
2006 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings suggest that GRIN2B may be associated with schizophrenia and interaction effects of the polymorphisms in hsa-miR-219, CAKM2G, GRIN2B and GRIN3A may confer susceptibility to schizophrenia in the Chinese Han population.
|
26257337 |
2015 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In a recent weighted burden analysis of exome-sequenced schizophrenia cases and controls, we noted modest statistical evidence for an enrichment of rare, functional variants in FYN, GRIN1, and GRIN2B in schizophrenia cases.
|
30664045 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
RGD |
The selective loss of NR2B protein and subsequent synaptic dysfunction weakens plPFC function during development and may underlie early cognitive impairments in SCZ models and patients.
|
28628228 |
2017 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The selective loss of NR2B protein and subsequent synaptic dysfunction weakens plPFC function during development and may underlie early cognitive impairments in SCZ models and patients.
|
28628228 |
2017 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
These results suggest that SLC1A1, GRIN2B, and interactions between the two may potentially confer a susceptibility to OC symptoms in schizophrenia patients receiving clozapine.
|
23660601 |
2013 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Association analysis of the genetic variants of the N-methyl D-aspartate receptor subunit 2b (NR2b) and treatment-refractory schizophrenia in the Chinese.
|
12824739 |
2003 |
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Changes in GRIN2B promoter methylation may represent an environmental influence contributing to glutamatergic dysfunction in psychosis and relate to lower cognitive performance in subjects with first-episode schizophrenia.
|
30785307 |
2019 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found decreased NR1 expression in all three illnesses, decreased NR2A in schizophrenia and major depression, and decreased NR2C in schizophrenia.We found no changes of NR2B or NR2D.
|
18033238 |
2008 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we investigated whether expression of this NR2B-associated trafficking complex might be abnormal in schizophrenia.
|
20347576 |
2010 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Genetic variation in the NR2B gene predicts reduced levels of the obligatory NR1 subunit, suggesting a novel mechanism by which the NR2B SNP may negatively influence other NMDAR subunit expression and reasoning ability in schizophrenia.
|
23070074 |
2013 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, we found that upon crack inhalation mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A and NR2B NMDA receptor subunits in the PFC.
|
28314129 |
2017 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
One possible source of compromised glutamatergic function in SZ is decreased surface expression of GluN2B-containing NMDARs.
|
22781170 |
2012 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Using mature miRNA profiling and quantitative real-time PCR (qRT-PCR) in the orbitofrontal cortex (OFC) of SCZ (N = 29; 20 male and 9 female), BD (N = 26; 12 male and 14 female), and unaffected control (N = 25; 21 male and 4 female) subjects, we uncovered that miR-223, an exosome-secreted miRNA that targets glutamate receptors, was increased at the mature miRNA level in the OFC of SCZ and BD patients with positive history of psychosis at the time of death and was inversely associated with deficits in the expression of its targets glutamate ionotropic receptor NMDA-type subunit 2B (GRIN2B) and glutamate ionotropic receptor AMPA-type subunit 2 (GRIA2).
|
31775160 |
2020 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the present work, we observed increased expression of NMDA NR2B subunit transcripts, and decreased expression of all three associated postsynaptic density protein transcripts in schizophrenia.
|
15054476 |
2004 |