Bipolar Disorder
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Using mature miRNA profiling and quantitative real-time PCR (qRT-PCR) in the orbitofrontal cortex (OFC) of SCZ (N = 29; 20 male and 9 female), BD (N = 26; 12 male and 14 female), and unaffected control (N = 25; 21 male and 4 female) subjects, we uncovered that miR-223, an exosome-secreted miRNA that targets glutamate receptors, was increased at the mature miRNA level in the OFC of SCZ and BD patients with positive history of psychosis at the time of death and was inversely associated with deficits in the expression of its targets glutamate ionotropic receptor NMDA-type subunit 2B (GRIN2B) and glutamate ionotropic receptor AMPA-type subunit 2 (GRIA2).
|
31775160 |
2020 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
BEFREE |
The pathway analysis provided overall negative findings, although several genes including GRIN2B showed high percentage of associated SNPs for BD-AUD.
|
26563126 |
2016 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Based on extant neuroimaging data, we hypothesized that GRIN2B risk allele is associated with reductions of brain white matter integrity in the frontal, parietal, temporal, and occipital regions and cingulate gyrus in BD.
|
24490167 |
2013 |
Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Based on extant neuroimaging data, we hypothesized that GRIN2B risk allele is associated with reductions of brain white matter integrity in the frontal, parietal, temporal, and occipital regions and cingulate gyrus in BD.
|
24490167 |
2013 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.
|
20537720 |
2011 |
Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.
|
20537720 |
2011 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
There is evidence of associations between single nucleotide polymorphisms (SNPs) in GRM3, GRIN2B, and DAOA genes and the diagnosis of BD.
|
20957330 |
2010 |
Bipolar Disorder
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Lack of association of three GRIN2B polymorphisms with bipolar disorder.
|
19005876 |
2009 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Lack of association of three GRIN2B polymorphisms with bipolar disorder.
|
19005876 |
2009 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
BEFREE |
Our results on chromosome 12p support GRIN2B as a candidate gene for bipolar disorder that needs further investigation.
|
18007143 |
2007 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Our results on chromosome 12p support GRIN2B as a candidate gene for bipolar disorder that needs further investigation.
|
18007143 |
2007 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
BEFREE |
In the perirhinal cortex we detected decreased expression of GluR5 in all three diagnoses, of GluR1, GluR3, NR2B in both BD and MDD, and decreased NR1 and NR2A in BD and MDD, respectively.
|
17299517 |
2007 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
LHGDN |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
BEFREE |
The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
|
16549338 |
2006 |
Bipolar Disorder
|
0.390 |
Biomarker
|
disease |
BEFREE |
There is also growing evidence for the role of DRD1, NMDA receptor genes (GRIN1, GRIN2A, GRIN2B), brain-derived neurotrophic factor (BDNF), and dopamine transporter (SLC6A3) in both schizophrenia and bipolar disorder.
|
15952869 |
2005 |