Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 AlteredExpression disease BEFREE Using mature miRNA profiling and quantitative real-time PCR (qRT-PCR) in the orbitofrontal cortex (OFC) of SCZ (N = 29; 20 male and 9 female), BD (N = 26; 12 male and 14 female), and unaffected control (N = 25; 21 male and 4 female) subjects, we uncovered that miR-223, an exosome-secreted miRNA that targets glutamate receptors, was increased at the mature miRNA level in the OFC of SCZ and BD patients with positive history of psychosis at the time of death and was inversely associated with deficits in the expression of its targets glutamate ionotropic receptor NMDA-type subunit 2B (GRIN2B) and glutamate ionotropic receptor AMPA-type subunit 2 (GRIA2). 31775160 2020
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease BEFREE The pathway analysis provided overall negative findings, although several genes including GRIN2B showed high percentage of associated SNPs for BD-AUD. 26563126 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease PSYGENET Based on extant neuroimaging data, we hypothesized that GRIN2B risk allele is associated with reductions of brain white matter integrity in the frontal, parietal, temporal, and occipital regions and cingulate gyrus in BD. 24490167 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 GeneticVariation disease BEFREE Based on extant neuroimaging data, we hypothesized that GRIN2B risk allele is associated with reductions of brain white matter integrity in the frontal, parietal, temporal, and occipital regions and cingulate gyrus in BD. 24490167 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease PSYGENET Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder. 20537720 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 GeneticVariation disease BEFREE Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder. 20537720 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease PSYGENET There is evidence of associations between single nucleotide polymorphisms (SNPs) in GRM3, GRIN2B, and DAOA genes and the diagnosis of BD. 20957330 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 GeneticVariation disease BEFREE Lack of association of three GRIN2B polymorphisms with bipolar disorder. 19005876 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease PSYGENET Lack of association of three GRIN2B polymorphisms with bipolar disorder. 19005876 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease BEFREE Our results on chromosome 12p support GRIN2B as a candidate gene for bipolar disorder that needs further investigation. 18007143 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease PSYGENET Our results on chromosome 12p support GRIN2B as a candidate gene for bipolar disorder that needs further investigation. 18007143 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease BEFREE In the perirhinal cortex we detected decreased expression of GluR5 in all three diagnoses, of GluR1, GluR3, NR2B in both BD and MDD, and decreased NR1 and NR2A in BD and MDD, respectively. 17299517 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease LHGDN The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder. 16549338 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease BEFREE The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder. 16549338 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.390 Biomarker disease BEFREE There is also growing evidence for the role of DRD1, NMDA receptor genes (GRIN1, GRIN2A, GRIN2B), brain-derived neurotrophic factor (BDNF), and dopamine transporter (SLC6A3) in both schizophrenia and bipolar disorder. 15952869 2005