CXCL1, C-X-C motif chemokine ligand 1, 2919

N. diseases: 315; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease BEFREE Thus, macrophage-FABP4 has a novel role in pulmonary host defense against P. aeruginosa infection by facilitating crosstalk between macrophages and neutrophils via regulation of macrophage CXCL1 production.-Liang, X., Gupta, K., Rojas Quintero, J., Cernadas, M., Kobzik, L., Christou, H., Pier, G. B., Owen, C. A., Çataltepe, S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. 30462529 2019
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease BEFREE We found that loss of ACE2 function in mouse lung in the setting of endotoxin inhalation led to activation of the DABK/BKB1R axis, release of proinflammatory chemokines such as C-X-C motif chemokine 5 (CXCL5), macrophage inflammatory protein-2 (MIP2), C-X-C motif chemokine 1 (KC), and TNF-α from airway epithelia, increased neutrophil infiltration, and exaggerated lung inflammation and injury. 28935640 2018
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 AlteredExpression disease BEFREE In contrast neutrophil infiltration in the lung is unaffected by platelet reduction, up-regulation of CXCL-1 (2·4-fold) and CCL5 (1·4-fold) acting as a compensatory mechanism in platelet-reduced mice during lung inflammation. 29325217 2018
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease BEFREE Mice deficient for chromosome 3 GBPs were unable to mount a rapid IL-1/chemokine (C-X-C motif) ligand 1 (CXCL1) response during Legionella-induced pneumonia, with defective bacterial clearance. 29972777 2018
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 AlteredExpression disease BEFREE AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001). 29843140 2018
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease BEFREE CONCLUSIONS S100A9 and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 and CXCL1 may contribute solely in mild pneumonia, and CCL5 and CXCL11 may contribute in severe pneumonia. 28381820 2017
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease BEFREE Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2. 26747783 2016
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease RGD Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat. 20728373 2010
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.580 Biomarker disease BEFREE Biologically significant amounts of GRO are present in vivo in the bronchoalveolar lavage fluid of rabbits with E. coli pneumonia; by in situ hybridization, GRO mRNA is detectable in infiltrating pulmonary leukocytes and bronchial epithelial cells. 8631900 1996
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic
0.500 Biomarker phenotype CTD_human Role of estrogen receptor-dependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage. 21192278 2011
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic
0.500 Biomarker phenotype RGD Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model. 21168948 2011
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.500 Biomarker disease CTD_human Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion. 16526316 2006
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.500 Biomarker disease RGD The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat. 10655268 2000
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.350 AlteredExpression disease BEFREE AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001). 29843140 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.350 Biomarker disease BEFREE We found that loss of ACE2 function in mouse lung in the setting of endotoxin inhalation led to activation of the DABK/BKB1R axis, release of proinflammatory chemokines such as C-X-C motif chemokine 5 (CXCL5), macrophage inflammatory protein-2 (MIP2), C-X-C motif chemokine 1 (KC), and TNF-α from airway epithelia, increased neutrophil infiltration, and exaggerated lung inflammation and injury. 28935640 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.350 AlteredExpression disease BEFREE In contrast neutrophil infiltration in the lung is unaffected by platelet reduction, up-regulation of CXCL-1 (2·4-fold) and CCL5 (1·4-fold) acting as a compensatory mechanism in platelet-reduced mice during lung inflammation. 29325217 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.350 Biomarker disease BEFREE Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2. 26747783 2016
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.350 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C3714636
Disease: Pneumonitis
Pneumonitis
0.350 Biomarker disease BEFREE In order to study the role of GRO cytokines in lung inflammation, we cloned the predominant rabbit GRO cDNA (RabGRO) from alveolar macrophages, expressed bioactive recombinant protein (rRabGRO) in Escherichia coli, and developed a sensitive and specific enzyme-linked immunosorbent assay for RabGRO protein. 8631900 1996
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.340 Biomarker disease BEFREE Neutrophils from patients with COPD showed enhanced chemotactic responses toward both CXCL1 and leukotriene B<sub>4</sub> compared with control cells. 30395484 2019
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.340 AlteredExpression disease BEFREE Sputum CXCL1 levels in COPD and ACO patients were higher than in IP patients, whereas sputum CXCL8 levels were not. 30676127 2018
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.340 Biomarker disease BEFREE Within this context, we now show increased expression of the C-X-C chemokines (CXCL1 and CXCL2) and their receptor CXCR2, and the intercellular cellular adhesion molecule-1 (ICAM-1), in the lung tissues of patients with COPD. 26747783 2016
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.340 Biomarker disease BEFREE The analysis of gene expressions using a qPCR array revealed that many cytokines contributing to the pathogenesis and systemic inflammation in chronic obstructive pulmonary disease (COPD), including CCL2, CCL20, CSF2, CXCL1, CXCL10, IL1B and TNFα, were down-regulated by MA130 but not by a PKCζ-inactive control compound. 27516147 2016
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.340 Biomarker disease CTD_human Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A. 23099361 2013