Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Thus, macrophage-FABP4 has a novel role in pulmonary host defense against P. aeruginosa infection by facilitating crosstalk between macrophages and neutrophils via regulation of macrophage CXCL1 production.-Liang, X., Gupta, K., Rojas Quintero, J., Cernadas, M., Kobzik, L., Christou, H., Pier, G. B., Owen, C. A., Çataltepe, S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia.
|
30462529 |
2019 |
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
We found that loss of ACE2 function in mouse lung in the setting of endotoxin inhalation led to activation of the DABK/BKB1R axis, release of proinflammatory chemokines such as C-X-C motif chemokine 5 (CXCL5), macrophage inflammatory protein-2 (MIP2), C-X-C motif chemokine 1 (KC), and TNF-α from airway epithelia, increased neutrophil infiltration, and exaggerated lung inflammation and injury.
|
28935640 |
2018 |
Pneumonia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
In contrast neutrophil infiltration in the lung is unaffected by platelet reduction, up-regulation of CXCL-1 (2·4-fold) and CCL5 (1·4-fold) acting as a compensatory mechanism in platelet-reduced mice during lung inflammation.
|
29325217 |
2018 |
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Mice deficient for chromosome 3 GBPs were unable to mount a rapid IL-1/chemokine (C-X-C motif) ligand 1 (CXCL1) response during Legionella-induced pneumonia, with defective bacterial clearance.
|
29972777 |
2018 |
Pneumonia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001).
|
29843140 |
2018 |
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
CONCLUSIONS S100A9 and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 and CXCL1 may contribute solely in mild pneumonia, and CCL5 and CXCL11 may contribute in severe pneumonia.
|
28381820 |
2017 |
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2.
|
26747783 |
2016 |
Pneumonia
|
0.580 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
Pneumonia
|
0.580 |
Biomarker
|
disease |
RGD |
Low intensity laser therapy (LILT) in vivo acts on the neutrophils recruitment and chemokines/cytokines levels in a model of acute pulmonary inflammation induced by aerosol of lipopolysaccharide from Escherichia coli in rat.
|
20728373 |
2010 |
Pneumonia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Biologically significant amounts of GRO are present in vivo in the bronchoalveolar lavage fluid of rabbits with E. coli pneumonia; by in situ hybridization, GRO mRNA is detectable in infiltrating pulmonary leukocytes and bronchial epithelial cells.
|
8631900 |
1996 |
Shock, Hemorrhagic
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
Role of estrogen receptor-dependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage.
|
21192278 |
2011 |
Shock, Hemorrhagic
|
0.500 |
Biomarker
|
phenotype |
RGD |
Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model.
|
21168948 |
2011 |
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
CTD_human |
Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion.
|
16526316 |
2006 |
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
RGD |
The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat.
|
10655268 |
2000 |
Pneumonitis
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001).
|
29843140 |
2018 |
Pneumonitis
|
0.350 |
Biomarker
|
disease |
BEFREE |
We found that loss of ACE2 function in mouse lung in the setting of endotoxin inhalation led to activation of the DABK/BKB1R axis, release of proinflammatory chemokines such as C-X-C motif chemokine 5 (CXCL5), macrophage inflammatory protein-2 (MIP2), C-X-C motif chemokine 1 (KC), and TNF-α from airway epithelia, increased neutrophil infiltration, and exaggerated lung inflammation and injury.
|
28935640 |
2018 |
Pneumonitis
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
In contrast neutrophil infiltration in the lung is unaffected by platelet reduction, up-regulation of CXCL-1 (2·4-fold) and CCL5 (1·4-fold) acting as a compensatory mechanism in platelet-reduced mice during lung inflammation.
|
29325217 |
2018 |
Pneumonitis
|
0.350 |
Biomarker
|
disease |
BEFREE |
Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2.
|
26747783 |
2016 |
Pneumonitis
|
0.350 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
Pneumonitis
|
0.350 |
Biomarker
|
disease |
BEFREE |
In order to study the role of GRO cytokines in lung inflammation, we cloned the predominant rabbit GRO cDNA (RabGRO) from alveolar macrophages, expressed bioactive recombinant protein (rRabGRO) in Escherichia coli, and developed a sensitive and specific enzyme-linked immunosorbent assay for RabGRO protein.
|
8631900 |
1996 |
Chronic Obstructive Airway Disease
|
0.340 |
Biomarker
|
disease |
BEFREE |
Neutrophils from patients with COPD showed enhanced chemotactic responses toward both CXCL1 and leukotriene B<sub>4</sub> compared with control cells.
|
30395484 |
2019 |
Chronic Obstructive Airway Disease
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Sputum CXCL1 levels in COPD and ACO patients were higher than in IP patients, whereas sputum CXCL8 levels were not.
|
30676127 |
2018 |
Chronic Obstructive Airway Disease
|
0.340 |
Biomarker
|
disease |
BEFREE |
Within this context, we now show increased expression of the C-X-C chemokines (CXCL1 and CXCL2) and their receptor CXCR2, and the intercellular cellular adhesion molecule-1 (ICAM-1), in the lung tissues of patients with COPD.
|
26747783 |
2016 |
Chronic Obstructive Airway Disease
|
0.340 |
Biomarker
|
disease |
BEFREE |
The analysis of gene expressions using a qPCR array revealed that many cytokines contributing to the pathogenesis and systemic inflammation in chronic obstructive pulmonary disease (COPD), including CCL2, CCL20, CSF2, CXCL1, CXCL10, IL1B and TNFα, were down-regulated by MA130 but not by a PKCζ-inactive control compound.
|
27516147 |
2016 |
Chronic Obstructive Airway Disease
|
0.340 |
Biomarker
|
disease |
CTD_human |
Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A.
|
23099361 |
2013 |