GSK3B, glycogen synthase kinase 3 beta, 2932

N. diseases: 393; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338831
Disease: Manic
Manic
0.340 Biomarker disease BEFREE Inhibition of GSK-3β on Behavioral Changes and Oxidative Stress in an Animal Model of Mania. 30027342 2019
CUI: C0338831
Disease: Manic
Manic
0.340 GeneticVariation disease BEFREE In mood disorder patients, the level of mania (in both acute and stabilized periods) and depression in stabilized periods was positively associated with GSK3B rs12630592 T only in FXR1 rs496250 A-allele carriers (Bonferroni-corrected interaction p=0.024, 0.052 and 0.017 respectively). 28242499 2017
CUI: C0338831
Disease: Manic
Manic
0.340 GeneticVariation disease BEFREE The impact of glycogen synthase kinase 3β gene on psychotic mania in bipolar disorder patients. 21549170 2011
CUI: C0338831
Disease: Manic
Manic
0.340 Biomarker disease BEFREE Several currently available animal models reproduce select behavioral facets of human mania as well as the abnormal glutamatergic neurotransmission and dysregulation of glycogen synthase kinase 3β that accompanies this disease. 29860313 2018
CUI: C0338831
Disease: Manic
Manic
0.340 Biomarker disease CTD_human Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. 20357757 2010