GSK3B, glycogen synthase kinase 3 beta, 2932

N. diseases: 393; N. variants: 25
Disease: Leukemogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.030 Biomarker disease BEFREE The complexities of GSK-3β function and interactions with PI3K/AKT/mTOR signaling, cell cycling, and apoptotic pathways are poorly understood in the context of lymphomagenesis and cancer therapeutics. 29383130 2017
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.030 Biomarker disease BEFREE We conclude that the GSK3β-dependent survival pathway might be sex-specific in normal immature population and flip-flopped upon leukemogenesis. 21725365 2012
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.030 PosttranslationalModification disease BEFREE Activation of β-catenin was linked to CML leukemogenesis and drug resistance through its BCR-ABL-dependent Y phosphorylation and impaired binding to GSK3β (glycogen synthase kinase 3β). 22262776 2012