|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combination of higher CG methylation levels of <i>LMO2_E148, IL10_P325</i>, and <i>GSTM1_P266</i> corresponded to the highest risk of asthma by 43.48%, compared to other combinations (16.67-23.08%) in the 3-way multi-factor dimensionality reduction (MDR) analysis.
|
31214241 |
2019 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits.
|
29557517 |
2018 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence.
|
27043549 |
2016 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Airway eosinophilia was similar in GSTM1+ and GSTM1null asthmatics.
|
25118837 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study demonstrates that the GSTM1 null genotype presents a protective effect against asthma development in girls, but the risk of asthma development increases significantly under prenatal TSE.
|
25328891 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Also, no association was detected between GSTT1 and GSTM1 polymorphisms and atopic conditions or asthma severity.
|
24559168 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis provides evidence that GSTM1 and GSTT1 polymorphisms may be risk factors for asthma.
|
23600494 |
2013 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individuals with asthma with the GSTM1 wild-type genotype had greater baseline and allergen-provoked airway neutrophilia and concentrations of myeloperoxidase than GSTM1-null patients.
|
23204253 |
2013 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis of the GSTM1 (n = 35), GSTT1 (n = 31) and GSTP1 (n = 28) studies suggests that no significant associations with asthma susceptibility were observed for GSTM1 and GSTP1 gene polymorphisms, whereas a significant outcome was detected for the GSTT1 positive/null genotype (pooled OR = 1.33, 95 %CI = 1.10-1.60).
|
23307299 |
2013 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to investigate the role of GSTT1 and GSTM1 gene polymorphisms in asthma pathogenesis in a North Indian population.
|
22484660 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Acute effects of walking environment and GSTM1 variants in children with asthma.
|
21196426 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the role of polymorphisms in the GSTT1, GSTM1 and GSTP1 genes and asthma susceptibility in Egyptian children, and to analyze their effect on GST activity and lung function.
|
22326267 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanate asthma.
|
21325943 |
2011 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Statistically significant associations with asthma were observed for SNPs in GSTM1, MS4A2, and GSTP1 genes, after correction for multiple testing.
|
21320344 |
2011 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GST1 (GSTT1) null genotypes were associated with current asthma (OR 1.43, 95% CI 1.00-2.04) and medication use (OR 1.46, 95% CI 1.01-2.22).
|
21109554 |
2011 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GSTA1*-69T and GSTO2*D142 variants are associated with the significant increased risk of asthma development in our study population, while GSTM1, GSTP1 and GSTT1 genotype distributions were nearly equal between the control group and asthmatics.
|
22040239 |
2011 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the associations of EPHX1 Tyr113His and His139Arg polymorphisms with asthma and wheezing outcomes, and focused on the functional genetic change in different ambient nitrogen dioxide (NO₂) levels on glutathione S-transferase p1 (GSTP1) and glutathione S-transferase m1 (GSTM1) genotypes.
|
21183608 |
2011 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the increased asthma risk associated with h0111101 was restricted to children with the GSTM1 "null" genotype (interaction p=0.002, HR 1.89, 95% CI 1.34 to 2.60).
|
19996333 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether common, functional polymorphisms in GSTM1, GSTP1 and NQO1 influence airway hyperreactivity (AHR) and atopy among schoolchildren in South Africa.
|
20526719 |
2010 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The meta-analyses of GSTM1 (n = 22 studies) and GSTT1 (n = 19) showed increased asthma risk associated with the null genotype, but there was extreme between-study heterogeneity and publication bias and the association disappeared when meta-analysis was restricted to the largest studies.
|
20032267 |
2010 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the increased risk of asthma and wheezing associated with late gestation acetaminophen exposure in the presence of maternal GSTM1 was further enhanced when GSTM1 was also present in the child.
|
21051083 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the current study, allelic polymorphisms of GSTM1 and GSTT1 were analyzed in three ethnic groups of North East (NE) India where a high prevalence of various cancers and other diseases such as hypertension, tuberculosis, and asthma have been reported.
|
20073549 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |