GSTM1, glutathione S-transferase mu 1, 2944

N. diseases: 627; N. variants: 9
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE Our findings indicate that GSTM1 may be a causal gene of both ATDH and SCZ, although further validation pertaining to other genes, such as CYP2E1 or DRD2, is necessary. 27580934 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE These results indicate that GSTM1 represents a genetic connection between ATDILI and SCZ, and suggest that ATDILI and SCZ may be co-occurring for the subjects with GSTM1 null genotype. 26046920 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE In conclusion, our meta-analysis indicated the GSTM1 polymorphism may be the only genetic risk factor for schizophrenia in East Asian population. 26295386 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE In agreement with a previous report, the present data indicate that gains in the CNV alleles DDTL and GSTM1 are genetic risk factors in Japanese patients with schizophrenia, and suggest involvement of micro-inflammation and oxidative stress in the pathophysiology of schizophrenia. 26175060 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Furthermore, the combination of the GSTM1 and GSTT1 null genotypes showed a non-significant trend to an increased risk of schizophrenia. 23107768 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Furthermore, the combination of the GSTM1 and GSTT1 null genotypes showed a non-significant trend to an increased risk of schizophrenia. 23107768 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease BEFREE We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines. 21093063 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines. 21093063 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET We isolated genomic DNA from peripheral blood of 93 individuals with SCZ and 99 healthy control subjects' genotypes analyzing them for GSTM1, GSTT1 and GSTP1 using polymerase chain reaction. 22874804 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2 (glutathione S-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P=0.0008). 19528963 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 Biomarker disease PSYGENET Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2 (glutathione S-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P=0.0008). 19528963 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE This study suggests that, at least in the Korean population, the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to tardive dyskinesia. 15318028 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.390 GeneticVariation disease BEFREE The frequency of the GSTM1*0 allele was significantly higher amongst the patients with schizophrenia compared to controls (P = 0.0075). 11181039 2001