GSTM1, glutathione S-transferase mu 1, 2944

N. diseases: 627; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE In total, 133 patients with MM treated with (n = 97) or without (n = 36) platinum-based therapy were genotyped for common XPD, ERCC1, and GSTP1 polymorphisms, as well as for GSTM1 and GSTT1 gene deletion. 21765044 2012
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE Combination of NAT2 fast acetylator and GSTM1 null genotype posed a significantly increased risk of MM in the Italian, but not in the Finnish study. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 Biomarker disease CTD_human Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma.Cancer Res.55, 2981-2983; Hirvonen et al., 1996. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE Individuals who lacked the GSTM1 gene and possessed a NAT2 slow-acetylator genotype had a risk of developing malignant and nonmalignant pulmonary disorders that was approximately fivefold greater than that observed for those who had the GSTM1 gene and a NAT2 fast-acetylator genotype (OR = 5.1; 95% CI = 1.6-17.6); these individuals had a fourfold increased risk of developing nonmalignant pulmonary disorders (OR = 4.1; 95% CI = 1.1-17.2) and an eightfold increased risk of developing malignant mesothelioma (OR = 7.8; 95% CI = 1.4-78.7) when compared with the same reference group. 8961976 1996
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE The individuals with combined GSTM1 and NAT2 defects had about a 4-fold risk of developing malignant mesothelioma compared to those with the GSTM1 gene and NAT2 fast acetylator genotype (OR = 3.6; 95% CI = 1.3-9.6). 7606714 1995