Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
H3.3 G34W mutant-specific immunohistochemistry is a highly sensitive and specific surrogate marker for H3F3A p.G34W mutation in GCTB and thus useful for differential diagnoses of histological mimics.
|
31748824 |
2020 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lack of H3F3A mutation eliminated the possibility of GCT-B metastasizing to the breast.
|
31784095 |
2020 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In chondroblastoma and giant cell tumour of bone, the neoplastic mononuclear stromal-like cells frequently harbour specific point mutations in the genes encoding for histone H3.3 (H3F3A and H3F3B).
|
31728625 |
2020 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The two H3F3A G34W-positive sarcomas without giant cell tumor histology involved the subarticular epiphyseal sites, suggesting relatedness with giant cell tumor of bone.
|
31285528 |
2019 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Examples include giant cell tumour of bone (H3F3A p.G34W), chondroblastoma (H3F3B p.K36M), mesenchymal chondrosarcoma (HEY1-NCOA2), chondromyxoid fibroma (GRM1 rearrangements), aneurysmal bone cyst (USP6 rearrangements), osteoblastoma/osteoid osteoma (FOS/FOSB rearrangements), and synovial chondromatosis (FN1-ACVR2A and ACVR2A-FN1).
|
30582658 |
2019 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Knock-down of oncohistone H3F3A-G34W counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells.
|
30742944 |
2019 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have established three new stable H3F3A mutated GCTB cell lines: U-GCT1, U-GCT2, and U-GCT3M.
|
31015476 |
2019 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Giant cell tumor of bone (GCTB)-related clonal aberrations occur in a background of epigenetic histone modifications (especially the G34W mutation of H3F3A gene) that induce cytogenetic abnormalities.
|
29944971 |
2018 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR).
|
29254795 |
2018 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the histopathological features and H3F3A mutation status of GCTBs treated with denosumab.
|
29206281 |
2018 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
After the discovery of RANKL, the concept of GCTB as a tumor of RANKL-expressing stromal cells was established, and comprehensive exosome studies finally disclosed the causative single-point mutation at histone H3.3 (H3F3A) in stromal cells.
|
29356963 |
2018 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among the other tumors studied, we only found H3F3A gene mutations in two cases of 'dedifferentiated chondrosarcoma mimicking giant cell tumor of the bone'.
|
28059095 |
2017 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One of two atypical GCTB cases with wild-type H3F3A had a H3F3B mutation (p.G34V).Other mutated genes were not recurrent.
|
28545165 |
2017 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We herein report a case of a benign recurrent GCTB with an H3F3A mutation that underwent secondary malignant transformation during treatment with denosumab.
|
29048579 |
2017 |
Giant Cell Tumor of Bone
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we confirm that H3F3A mutational testing may be a useful adjunct to differentiate GCTB from giant cell-rich sarcomas.
|
28899740 |
2017 |
Giant Cell Tumor of Bone
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, somatic driver mutations of histone H3.3 exclusively in H3F3A have been described in GCTB.
|
27020452 |
2016 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that H3F3A and H3F3B mutation analysis appears to be a highly specific, although less sensitive, diagnostic tool for the distinction of GCTB and chondroblastoma from other giant cell-containing tumors.
|
26457357 |
2015 |
Giant Cell Tumor of Bone
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
|
24162739 |
2013 |
Giant Cell Tumor of Bone
|
0.400 |
Biomarker
|
disease |
CTD_human |
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.
|
24162739 |
2013 |