Angelman Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice.
|
31849603 |
2019 |
Impaired cognition
|
0.020 |
Biomarker
|
disease |
BEFREE |
Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice.
|
31849603 |
2019 |
Cognition Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice.
|
31849603 |
2019 |
Leukemia, Myelocytic, Acute
|
0.090 |
Biomarker
|
disease |
BEFREE |
ANRIL promotes AML development through HDAC1-mediated epigenetic suppression of ASPP2 via negatively regulating miR-34a, which might serve as a therapeutic target for AML treatment.
|
31830533 |
2020 |
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Due to their effective roles in the onset of cancer and its progression, HDAC Class I isoforms (HDAC 1, 2, 3 and 8) were considered in this study.
|
31773377 |
2019 |
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Due to their effective roles in the onset of cancer and its progression, HDAC Class I isoforms (HDAC 1, 2, 3 and 8) were considered in this study.
|
31773377 |
2019 |
Amyotrophic Lateral Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study showed that nucleic transport of DNA repair- processing proteins, such as p53, APEX1, HDAC1, and ALS- linked FUS were interfered with under increased endoplasmic reticulum (ER) stress in the presence of SOD1G93A.
|
31771229 |
2019 |
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results indicated that RFX1 expression deficiency in CD14+ monocytes from CAD patients contributed to MCP1 overexpression <i>via</i> a deficiency of recruitments of HDAC1 and SUV39H1 in the <i>MCP1</i> promoter, which highlighted the vital role of RFX1 in the pathogenesis of CAD.
|
31737059 |
2019 |
Intrahepatic Cholangiocarcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown a link between hypoxia and CA19-9 in cancer, and we have previously demonstrated a correlation between HDAC1 and HIF-1α in IHCC.
|
31704828 |
2019 |
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.020 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown a link between hypoxia and CA19-9 in cancer, and we have previously demonstrated a correlation between HDAC1 and HIF-1α in IHCC.
|
31704828 |
2019 |
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ARID1A and histone deacetylase 1 were directly recruited to the ALDH1A1 promoter region in cholangiocarcinoma cells with undetectable ALDH1A expression by chromatin immunoprecipitation assay.
|
31665232 |
2019 |
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression <i>in silico</i>.
|
31637215 |
2019 |
Glioblastoma Multiforme
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
The expression of DECR1 and POLR2F was significantly lower, while the levels of HDAC1 and PDIA3 were highly expressed in GBM tissues.
|
31633244 |
2020 |
Glioblastoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The expression of DECR1 and POLR2F was significantly lower, while the levels of HDAC1 and PDIA3 were highly expressed in GBM tissues.
|
31633244 |
2020 |
Liposarcoma, Dedifferentiated
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i>, treatment of DDLPS cell lines with the HDAC inhibitors MI-192 (HDAC2/3 inhibitor) or romidepsin (HDAC1/2 inhibitor) reduced <i>MDM2</i> expression and induced apoptosis.
|
31620242 |
2019 |
Mitochondrial Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The present results suggest that the inhibition of HDAC1 suppresses the pathogenic processes that lead to the degeneration of motoneurons in mitochondrial diseases.
|
31614134 |
2019 |
Asthma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings demonstrated that PMCS exacerbated asthma in mice by increasing H3K9 and H3K14 acetylation in IL-4 gene promoter in CD4 + T cells, and P300 and HDAC1 might contribute to their combined effects.
|
31520700 |
2019 |
Tumor Progression
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The NuRD chromatin remodeling and deacetylation complex, which includes MTA1, MBD3, CHD4, and HDAC1 among other components, is of importance for development and cancer progression.
|
31519689 |
2019 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.050 |
Biomarker
|
disease |
BEFREE |
Collectively, our data show that inhibition of multiple HDACs is required for therapeutic effects of HDAC inhibitors and support the development of novel strategies to inhibit HDACs 1, 2, and 6 for PDAC therapy.
|
31500290 |
2019 |
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Enhancer of zeste homolog 2 and HDAC1 mRNA expression in two lung adenocarcinoma (LUAD) datasets (MDACC and TCGA) were correlated with patient outcomes.
|
31456359 |
2019 |
Non-small cell lung cancer stage I
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with high EZH2 and high HDAC1 expression in stage I NSCLC specimens of both datasets had the lowest survival compared to the patients with low expression of either or both markers.
|
31456359 |
2019 |
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Profilin 2a (PFN2a) is a ubiquitous actin monomer-binding protein and promotes lung cancer growth and metastasis through suppressing the nuclear localization of histone deacetylase 1 (HDAC1).
|
31450751 |
2019 |
Liver carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, HDAC1 promoter activity and binding in HCC cell lines were detected by luciferase reporter assay and chromatin immunoprecipitation (ChIP), respectively.
|
31440094 |
2019 |
Human immunodeficiency virus (HIV) II infection category B1
|
0.010 |
Biomarker
|
disease |
BEFREE |
RBBP4 binds to the HIV-1 long terminal repeat (LTR), represses HIV-1 LTR-mediated transcription through recruiting nuclear receptor subfamily 2 group F member 1(NR2F1) and histone deacetylase 1 and 2 (HDAC1/2) to HIV-1 LTR, and further controls local histone 3 (H3) deacetylation and chromatin compaction.
|
31435636 |
2019 |
Angioimmunoblastic Lymphadenopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results revealed that 55.8% of patients with PTCL-NOS, 57.1% of patients with NK/TCL, 86.7% of patients ALCL and 50% of patients with AITL highly expressed HDAC1.
|
31423206 |
2019 |