Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 AlteredExpression disease BEFREE Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. 27959513 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 AlteredExpression disease BEFREE In summary, we suggest that reduced p35 expression in schizophrenia has an impact on synaptic protein expression and cognition and that these deficits can be rescued, at least in part, by the inhibition of histone deacetylase 1. 21772061 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease BEFREE Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model. 26812044 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease BEFREE HDAC1 links early life stress to schizophrenia-like phenotypes. 28533418 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease PSYGENET Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease. 23664640 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 AlteredExpression disease LHGDN The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. 17961987 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 AlteredExpression disease BEFREE The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. 17961987 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease PSYGENET HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. 17961987 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 Biomarker disease CTD_human Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. 21527555 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 AlteredExpression disease BEFREE Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. 21527555 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 AlteredExpression disease BEFREE In this study, we show that vorinostat (2 μM) reduced expression of HDAC1, 2, 3, and 7 in epidermoid carcinoma A431 cells. 23147569 2013
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 AlteredExpression disease LHGDN histone deacetylase 1 overexpression is associated with advanced stage esophageal squamous cell carcinoma. 12579268 2003
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.310 AlteredExpression disease BEFREE HDAC1 and HDAC2 are differentially expressed in endometriosis. 22344732 2012
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.310 Biomarker disease CTD_human Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis. 22138541 2012
CUI: C0269102
Disease: Endometrioma
Endometrioma
0.310 Biomarker disease CTD_human Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis. 22138541 2012
CUI: C0269102
Disease: Endometrioma
Endometrioma
0.310 AlteredExpression disease BEFREE Histone deacetylase-1 target mRNAs that were up-regulated by valproic acid (VPA) treatment in endometriotic cyst stromal cells (ECSCs) were identified by a global mRNA microarray technique. 23833041 2013
Familial primary pulmonary hypertension
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
Pulmonary Hypertension, Primary, Fenfluramine-Associated
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
Idiopathic pulmonary arterial hypertension
0.300 Biomarker disease CTD_human HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia. 22711276 2012
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 AlteredExpression disease BEFREE These results imply that HDAC1 mRNA expression could have potential as an endocrine response marker and may have prognostic implications for breast cancer progression. 16172792 2006
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 AlteredExpression disease BEFREE pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. 12789259 2003
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. 15557281 2005
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 AlteredExpression disease BEFREE We also found that the expression level of HDACs 1-3 was higher in breast cancer cell lines than in normal breast epithelial cells. 17230502 2007