Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0950123
Disease: Genetic Diseases, Inborn
Genetic Diseases, Inborn
0.100 GeneticVariation group CLINVAR
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.060 GeneticVariation disease BEFREE TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. 17079440 2006
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.050 GeneticVariation disease BEFREE TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming. 17079440 2006
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.020 GeneticVariation disease BEFREE The HBV-core protein and HBV DNA localized to PML-NBs, where they associated with PML and histone deacetylase 1 (HDAC1). 19808906 2010
CUI: C0205824
Disease: Liposarcoma, Dedifferentiated
Liposarcoma, Dedifferentiated
0.010 GeneticVariation disease BEFREE While the point mutation rate was modest, integrative analyses and additional screening identified somatic mutations in HDAC1 in 8.3% of DLPS. 22328974 2012
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.010 GeneticVariation phenotype BEFREE Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. 20731616 2011
CUI: C3888194
Disease: MIXED LINEAGE LEUKEMIA
MIXED LINEAGE LEUKEMIA
0.010 GeneticVariation disease BEFREE These changes were accompanied by increased p300 (EP300), histone deacetylase 1 (HDAC1), myeloid/lymphoid or mixed lineage leukemia (MLL), SET7/9 (SETD7), G9A (EHMT2), JMJD2C (KDM4C) and JARID1A (KDM5A) expression, as well as reduced HDAC2, HDAC7, LSD1 (KDM1A), JMJD2A (KDM4A) and JMJD2B (KDM4B) expression. 21936853 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease BEFREE Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model. 26812044 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease BEFREE HDAC1 links early life stress to schizophrenia-like phenotypes. 28533418 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease PSYGENET Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease. 23664640 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.350 Biomarker disease PSYGENET HDAC1 expression levels were significantly higher in schizophrenia versus normal subjects. 17961987 2008
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 Biomarker disease CTD_human Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma. 21527555 2011
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.310 Biomarker disease CTD_human Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis. 22138541 2012
CUI: C0269102
Disease: Endometrioma
Endometrioma
0.310 Biomarker disease CTD_human Nuclear receptor, coregulator signaling, and chromatin remodeling pathways suggest involvement of the epigenome in the steroid hormone response of endometrium and abnormalities in endometriosis. 22138541 2012
CUI: C0018799
Disease: Heart Diseases
Heart Diseases
0.300 Biomarker group CTD_human Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. 18625706 2008
Familial primary pulmonary hypertension
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.300 Biomarker group PSYGENET These results provide evidence that selective inhibition of HDAC1 and HDAC2 in brain may provide an epigenetic-based target for developing improved treatments for mood disorders and other brain disorders with altered chromatin-mediated neuroplasticity. 23967191 2014
PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
Pulmonary Hypertension, Primary, Fenfluramine-Associated
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
Idiopathic pulmonary arterial hypertension
0.300 Biomarker disease CTD_human HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia. 22711276 2012
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
CUI: C0020542
Disease: Pulmonary Hypertension
Pulmonary Hypertension
0.200 Biomarker phenotype RGD Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. 15557281 2005
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8. 28779562 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer. 28870936 2017