|
Actinic cheilitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
HDAC1 and HAT1 nuclear immunostaining were higher in AC, with no statistical significance.
|
28107582 |
2017 |
|
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
HDAC1 and HDAC4 showed high expression in T-ALL and HDAC5 was highly expressed in B-lineage ALL.
|
20636436 |
2010 |
|
Acute lymphocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that histone deacetylase-1 (HDAC1) is recruited by NFY and Sp1 transcription factors to the FPGS promoter in ALL cell lines.
|
20072153 |
2010 |
|
Acute lymphocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Overall, our novel mechanistic and preclinical studies together demonstrate that HDAC1,2 selective inhibition can overcome DSB repair 'addiction' and provide an effective therapeutic option for Ph+ B-cell precursor ALL.
|
28579617 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FAZF is homologous to the promyelocytic leukemia zinc finger (PLZF) protein, which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and HDAC1 complex).
|
10572087 |
1999 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In human colon polyps and adenocarcinomas, miR-22 and RARβ were consistently reduced, which was associated with elevated HDAC1, HDAC4, and SIRT1 in colon adenocarcinomas.
|
30252536 |
2019 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In addition, the protein expression level of HDAC1 in squamous cell carcinoma was higher than that in adenocarcinoma (OR = 1.81, 95% CI = 1.13-2.90, P = .01).
|
28767587 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Histone deacetylase 1/Sp1/microRNA-200b signaling accounts for maintenance of cancer stem-like cells in human lung adenocarcinoma.
|
25279705 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Stronger HDAC1 expression by tumor cells is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung.
|
21466904 |
2011 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Enhancer of zeste homolog 2 and HDAC1 mRNA expression in two lung adenocarcinoma (LUAD) datasets (MDACC and TCGA) were correlated with patient outcomes.
|
31456359 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.040 |
Biomarker
|
disease |
BEFREE |
Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549.
|
24265759 |
2013 |
|
Adenocarcinoma of pancreas
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of HDAC1,2,3,4,7 and Nur77 increased in PA samples at levels significantly higher than those observed in the CP group (p = 0.0160; 0.0114; 0.0227; 0.0440; 0.0136; 0.0004, respectively).
|
25275504 |
2014 |
|
Adenocarcinoma of pancreas
|
0.030 |
Biomarker
|
disease |
BEFREE |
The goal of this study is to determine the functional role of HDAC1 in normal development of exocrine pancreas using zebrafish as the model organism as well as in human pancreatic adenocarcinoma.
|
21301206 |
2011 |
|
Adenocarcinoma of pancreas
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to evaluate the clinical significance of HDAC-1, -2, -4 and -6 protein expression in pancreatic adenocarcinoma.
|
26502922 |
2015 |
|
Adult Acute Lymphocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overall, our novel mechanistic and preclinical studies together demonstrate that HDAC1,2 selective inhibition can overcome DSB repair 'addiction' and provide an effective therapeutic option for Ph+ B-cell precursor ALL.
|
28579617 |
2018 |
|
Adult Acute Lymphocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that histone deacetylase-1 (HDAC1) is recruited by NFY and Sp1 transcription factors to the FPGS promoter in ALL cell lines.
|
20072153 |
2010 |
|
Adult Classical Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of HDAC1 was correlated negatively with progression-free survival and OS, and increased expression of HDAC11 had a borderline relationship with the OS rate in patients with cHL.
|
29481474 |
2018 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Histone deacetylase 1 and histone 3 were more strongly detected in hepatocellular carcinoma tissue and fibrosarcoma cells than in liver tissues and fibroblast cells, respectively.
|
25792651 |
2015 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that HDAC1 may be a novel biomarker and potential therapeutic target in glioblastoma.
|
29782850 |
2018 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that the downregulation of RFP or the disruption of the RFP/HDAC1 complex leads to an increase in TMZ efficacy in glioblastoma by changing histone modifications which lead to changes in cell division, cell cycle and apoptosis.
|
31178471 |
2019 |
|
Adult Hodgkin Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, decreased HDAC1 expression is accompanied by worse outcome in HL.
|
20415600 |
2010 |
|
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we demonstrated overexpression of HDAC1 in a subset of human HCCs and liver cancer cell lines.
|
22496786 |
2012 |
|
Adult Liver Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In livers of young mice, CUGBP1 forms complexes with eukaryotic translation initiation factor eIF2 and supports translation of C/EBPβ and HDAC1 proteins, which are involved in liver growth, differentiation and liver cancer.
|
22446383 |
2012 |
|
Adult Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In search of a cell line in which the D3 dopamine receptor is expressed endogenously, we found that the neuron-derived human medulloblastoma cell line TE671 expresses the human D3 (hD3) and D1 (hD1) receptor, but neither the D2 or D4 receptors.
|
9849894 |
1998 |
|
Adult Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The putative tumor suppressor REN(KCTD11) acts through ubiquitination-dependent degradation of HDAC1, thereby affecting Hh activity and medulloblastoma growth.
|
21472142 |
2011 |