Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0950123
Disease: Genetic Diseases, Inborn
Genetic Diseases, Inborn
0.100 GeneticVariation group CLINVAR
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma
0.030 Biomarker disease BEFREE In search of a cell line in which the D3 dopamine receptor is expressed endogenously, we found that the neuron-derived human medulloblastoma cell line TE671 expresses the human D3 (hD3) and D1 (hD1) receptor, but neither the D2 or D4 receptors. 9849894 1998
CUI: C2745900
Disease: Promyelocytic leukemia
Promyelocytic leukemia
0.030 AlteredExpression disease BEFREE FAZF is homologous to the promyelocytic leukemia zinc finger (PLZF) protein, which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and HDAC1 complex). 10572087 1999
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia
0.010 AlteredExpression disease BEFREE FAZF is homologous to the promyelocytic leukemia zinc finger (PLZF) protein, which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and HDAC1 complex). 10572087 1999
CUI: C2745900
Disease: Promyelocytic leukemia
Promyelocytic leukemia
0.030 Biomarker disease BEFREE Here we show that PML interacts with multiple corepressors (c-Ski, N-CoR, and mSin3A) and histone deacetylase 1, and that this interaction is required for transcriptional repression mediated by the tumor suppressor Mad. 11430826 2001
Leukoencephalopathy, Progressive Multifocal
0.020 Biomarker disease BEFREE Here we show that PML interacts with multiple corepressors (c-Ski, N-CoR, and mSin3A) and histone deacetylase 1, and that this interaction is required for transcriptional repression mediated by the tumor suppressor Mad. 11430826 2001
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.020 AlteredExpression group LHGDN Expression profile of histone deacetylase 1 in gastric cancer tissues 11749695 2002
CUI: C0278488
Disease: Carcinoma breast stage IV
Carcinoma breast stage IV
0.010 AlteredExpression disease BEFREE Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex. 11896613 2002
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.020 AlteredExpression group LHGDN associated with silencing DAP kinase gene expression in colorectal and gastric cancers 12087472 2002
CUI: C0004096
Disease: Asthma
Asthma
0.020 AlteredExpression disease BEFREE There was no difference in the site of HDAC1-HDAC6 expression between normal subjects and subjects with asthma, but subjects with asthma had reduced HDAC enzymatic activity and reduced HDAC1 and HDAC2 protein expression, as measured by Western blotting. 12153977 2002
CUI: C0030521
Disease: Parathyroid Neoplasms
Parathyroid Neoplasms
0.010 AlteredExpression group BEFREE The mapping of HDAC1 centromeric of the main interval, and the lack of altered mRNA expression in tumors with LOH, suggest that HDAC1 is not the main target for 1p deletions in parathyroid tumors. 12239610 2003
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.330 AlteredExpression disease LHGDN histone deacetylase 1 overexpression is associated with advanced stage esophageal squamous cell carcinoma. 12579268 2003
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma
0.030 Biomarker disease BEFREE Furthermore, we determined that HDAC1 complexed with Sp1 in PDAC cells and that TSA treatment interfered with this association. 12750289 2003
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 AlteredExpression disease BEFREE pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. 12789259 2003
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 AlteredExpression disease BEFREE pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. 12789259 2003
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma
0.030 AlteredExpression disease BEFREE Taken together, our results indicate that Che-1 can be considered a general HDAC1 competitor and its down-regulation is involved in colon carcinoma cell proliferation. 12847090 2003
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.050 AlteredExpression disease BEFREE Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line. 13679859 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.020 AlteredExpression group LHGDN HDAC1 upregulated in pre-malignant and malignant lesions, with the highest increase in expression in hormone refractory (HR) prostate cancer; in CWR22 xenograft model, androgen dependent regulation of HDAC1 demonstrated. 15042618 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.020 Biomarker group LHGDN histone deacetylase has a role in transforming growth factor-beta signaling in breast cancer cells 15155736 2004
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.050 AlteredExpression disease BEFREE Histone deacetylase 1 mRNA expression in lung cancer. 15474665 2005
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung
0.050 AlteredExpression disease BEFREE Histone deacetylase 1 mRNA expression in lung cancer. 15474665 2005
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung
0.040 AlteredExpression disease BEFREE Histone deacetylase 1 mRNA expression in lung cancer. 15474665 2005
CUI: C0862824
Disease: Lung cancer stage I
Lung cancer stage I
0.010 AlteredExpression disease BEFREE The HDAC1/GAPDH mRNA levels were significantly higher in stage III or IV lung cancer (50.929 +/- 120.433) than in stage I lung cancer (11.430 +/- 25.611, P = 0.0472). 15474665 2005
CUI: C0025202
Disease: melanoma
melanoma
0.040 AlteredExpression disease BEFREE Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway. 15520174 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. 15557281 2005