Medulloblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
In search of a cell line in which the D3 dopamine receptor is expressed endogenously, we found that the neuron-derived human medulloblastoma cell line TE671 expresses the human D3 (hD3) and D1 (hD1) receptor, but neither the D2 or D4 receptors.
|
9849894 |
1998 |
Childhood Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In search of a cell line in which the D3 dopamine receptor is expressed endogenously, we found that the neuron-derived human medulloblastoma cell line TE671 expresses the human D3 (hD3) and D1 (hD1) receptor, but neither the D2 or D4 receptors.
|
9849894 |
1998 |
Adult Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In search of a cell line in which the D3 dopamine receptor is expressed endogenously, we found that the neuron-derived human medulloblastoma cell line TE671 expresses the human D3 (hD3) and D1 (hD1) receptor, but neither the D2 or D4 receptors.
|
9849894 |
1998 |
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FAZF is homologous to the promyelocytic leukemia zinc finger (PLZF) protein, which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and HDAC1 complex).
|
10572087 |
1999 |
Promyelocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FAZF is homologous to the promyelocytic leukemia zinc finger (PLZF) protein, which has been shown to act as a transcriptional repressor by recruitment of nuclear corepressors (N-CoR, Sin3, and HDAC1 complex).
|
10572087 |
1999 |
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Mutations and alterations of the IGF-axis as well as of chromosome 1p34, where the genes for histone deacetylase 1 (HDAC1) and transforming growth factor beta receptor interacting protein-1 (TRIP-1) map, are frequent events in hepatocarcinogenesis.
|
10601571 |
2000 |
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, the present study clearly demonstrates that HDAC1 is overexpressed in GC and probably plays a significant role in gastric carcinogenesis.
|
11749695 |
2001 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we show that PML interacts with multiple corepressors (c-Ski, N-CoR, and mSin3A) and histone deacetylase 1, and that this interaction is required for transcriptional repression mediated by the tumor suppressor Mad.
|
11430826 |
2001 |
Malignant neoplasm of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is the first report to demonstrate that DNMT1 and HDAC1 levels are up-regulated in prostate cancer compared to BPH, suggesting their roles in inactivation of various genes, by DNA-methylation-induced chromatin-remodeling, in prostate cancer.
|
11563853 |
2001 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, the present study clearly demonstrates that HDAC1 is overexpressed in GC and probably plays a significant role in gastric carcinogenesis.
|
11749695 |
2001 |
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is the first report to demonstrate that DNMT1 and HDAC1 levels are up-regulated in prostate cancer compared to BPH, suggesting their roles in inactivation of various genes, by DNA-methylation-induced chromatin-remodeling, in prostate cancer.
|
11563853 |
2001 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, the present study clearly demonstrates that HDAC1 is overexpressed in GC and probably plays a significant role in gastric carcinogenesis.
|
11749695 |
2001 |
Leukoencephalopathy, Progressive Multifocal
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we show that PML interacts with multiple corepressors (c-Ski, N-CoR, and mSin3A) and histone deacetylase 1, and that this interaction is required for transcriptional repression mediated by the tumor suppressor Mad.
|
11430826 |
2001 |
Stomach Neoplasms
|
0.020 |
AlteredExpression
|
group |
LHGDN |
Expression profile of histone deacetylase 1 in gastric cancer tissues.
|
11749695 |
2001 |
Benign Prostatic Hyperplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This is the first report to demonstrate that DNMT1 and HDAC1 levels are up-regulated in prostate cancer compared to BPH, suggesting their roles in inactivation of various genes, by DNA-methylation-induced chromatin-remodeling, in prostate cancer.
|
11563853 |
2001 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mapping of HDAC1 centromeric of the main interval, and the lack of altered mRNA expression in tumors with LOH, suggest that HDAC1 is not the main target for 1p deletions in parathyroid tumors.
|
12239610 |
2002 |
Asthma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
There was no difference in the site of HDAC1-HDAC6 expression between normal subjects and subjects with asthma, but subjects with asthma had reduced HDAC enzymatic activity and reduced HDAC1 and HDAC2 protein expression, as measured by Western blotting.
|
12153977 |
2002 |
Stomach Neoplasms
|
0.020 |
AlteredExpression
|
group |
LHGDN |
DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers.
|
12087472 |
2002 |
Parathyroid Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The mapping of HDAC1 centromeric of the main interval, and the lack of altered mRNA expression in tumors with LOH, suggest that HDAC1 is not the main target for 1p deletions in parathyroid tumors.
|
12239610 |
2002 |
Carcinoma breast stage IV
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex.
|
11896613 |
2002 |
Squamous cell carcinoma
|
0.320 |
AlteredExpression
|
disease |
LHGDN |
Histone H4 acetylation and histone deacetylase 1 expression in esophageal squamous cell carcinoma.
|
12579268 |
2003 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.
|
12789259 |
2003 |
Malignant neoplasm of prostate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first report demonstrating that CXXC sequence containing MBD1 is overexpressed and can be the major factor of hypermethylated chromatin segments through HDAC1/2 translocation and histone deacetylation in human prostate cancer.
|
12646234 |
2003 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is the first report demonstrating that CXXC sequence containing MBD1 is overexpressed and can be the major factor of hypermethylated chromatin segments through HDAC1/2 translocation and histone deacetylation in human prostate cancer.
|
12646234 |
2003 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer.
|
12789259 |
2003 |