|
Adult Teratoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This holds true also in testicular tumors, where HDAC1 has been demonstrated in embryonal carcinoma, seminoma and teratoma.
|
16960727 |
2007 |
|
Adult Teratoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Increased levels of the transcriptional regulator SNAIL1 are crucial for enhanced proliferation and reduced differentiation of HDAC1-deficient teratoma.
|
20967026 |
2010 |
|
Alcohol Use Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study demonstrated that a new compound designed to target HDAC-1 is effective in reducing ethanol intake and relapse in rats and further confirm the interest of pursuing research to study the exact mechanism by which such inhibitor may be useful to treat AUDs.
|
29713786 |
2018 |
|
Allergic rhinitis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Trek1 was lower, whereas HDAC1 was higher in patients with allergic rhinitis as compared with healthy controls.
|
25529528 |
2015 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, analysis of the GSE48350 dataset confirmed similar changes in HDAC1, CDC42 and YES1 expression in Alzheimer's disease, thereby providing a molecular connection between aging and Alzheimer's disease (AD).
|
30341976 |
2018 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease.
|
28186506 |
2017 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Supplementation of nerve factors BMP7, FGF2, and FGF8 in the stump ends after amputation on denervated limbs not only enabled HDAC1 up-regulation but also led to more extent of limb regeneration.
|
30826398 |
2019 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A common familial ALS-associated FUS mutation (FUS-R521C) is revealed to prefer to cooperate with RBM45 than HDAC1.
|
29140459 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study showed that nucleic transport of DNA repair- processing proteins, such as p53, APEX1, HDAC1, and ALS- linked FUS were interfered with under increased endoplasmic reticulum (ER) stress in the presence of SOD1G93A.
|
31771229 |
2019 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using transgenic mice expressing a common FALS-associated FUS mutation (FUS-R521C mice), we found that mutant FUS proteins formed a stable complex with WT FUS proteins and interfered with the normal interactions between FUS and histone deacetylase 1 (HDAC1).
|
24509083 |
2014 |
|
Anaplastic thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show that HDACs 1 and 2 are overexpressed in ATCs compared with normal cells or benign tumors and that HDAC inhibitors induce apoptosis selectively in the fully transformed thyroid cells.
|
19802013 |
2010 |
|
Angelman Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here we report that the absence of Ube3a in AS mice brain caused aberrant increase in HDAC1/2 along with decreased acetylation of histone H3/H4.
|
28576709 |
2017 |
|
Angelman Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Restoration of HDAC1 and HDAC2 activities (as evident from the increased acetylation of histones H3 and H4) using simvastatin significantly improves the cognitive deficit and social interaction behavior in AS mice.
|
31849603 |
2019 |
|
Angioimmunoblastic Lymphadenopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results revealed that 55.8% of patients with PTCL-NOS, 57.1% of patients with NK/TCL, 86.7% of patients ALCL and 50% of patients with AITL highly expressed HDAC1.
|
31423206 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.050 |
Biomarker
|
disease |
BEFREE |
Collectively, our data show that inhibition of multiple HDACs is required for therapeutic effects of HDAC inhibitors and support the development of novel strategies to inhibit HDACs 1, 2, and 6 for PDAC therapy.
|
31500290 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.050 |
Biomarker
|
disease |
BEFREE |
We show that HDAC2, but not HDAC1, confers resistance towards the topoisomerase II inhibitor etoposide in PDAC cells.
|
19528037 |
2009 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
TSA or SAHA inhibited vimentin, HDACs 1, 7 and 8, upregulated E-cadherin mRNA and protein levels in the PDAC cells, and time-dependently downregulated Oct-4, Sox-2, and Nanog, as well as inhibited PDAC tumorsphere formation.
|
29374219 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.050 |
Biomarker
|
disease |
BEFREE |
Furthermore, we determined that HDAC1 complexed with Sp1 in PDAC cells and that TSA treatment interfered with this association.
|
12750289 |
2003 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.050 |
Biomarker
|
disease |
BEFREE |
In particular, class-I HDACs (HDAC 1, 2, 3 and 8) have been shown to play an important role in PDAC.
|
28369619 |
2017 |
|
Anoxia
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Protein kinase CK2 is a key activator of histone deacetylase in hypoxia-associated tumors.
|
17935135 |
2008 |
|
Aortic Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05).
|
31001930 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also examined the expression of mRNA encoding enzymes that catalyze making and removing epigenetic modifications by real-time PCR: we found that mRNA levels of DNA methyltransferase (DNMT) 1 and DNMT3A were higher in the AAA than in the HC group, mRNA levels of methyl-CpG-binding domain protein (MBD) 2 and MBD4 were higher in the AAA than in the HC group (MBD2: 6.21 ± 2.57 vs 3.04 ± 1.45; MBD4: 7.76 ± 3.48 vs 4.97 ± 3.10; both P < 0.05), and mRNA levels of histone deacetylase (HDAC) 1 and HDAC5 were significantly up-regulated in the AAA compared with the HC group (HDAC1: 2.17 ± 1.18 vs 1.51 ± 0.99; HDAC5: 1.35 ± 0.49 vs 0.94 ± 0.76; both P < 0.05).
|
31001930 |
2019 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the effects of homocysteine (Hcy) on the expression of histone deacetylase 1 (HDAC1) and tested our hypothesis that Hcy-induced atherosclerosis is mediated by increased HDAC1 expression, which is regulated by miR-34a.
|
28485501 |
2017 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Inhibition of miR‑34a prevents endothelial cell apoptosis by directly targeting HDAC1 in the setting of atherosclerosis.
|
29328474 |
2018 |
|
Asthma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In the PPI network, F‑box only protein 6 (FBXO6), histone deacetylase 1 (HDAC1) and amyloid β precursor protein (APP) were hub genes and served an important role in the process of asthma.
|
29956778 |
2018 |