HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders
0.010 AlteredExpression group BEFREE Taken together, these data expand our understanding of HDAC1-3 inhibitor binding kinetics, and further delineate the specific combinations of structural and kinetic features of HDAC inhibitors that are optimal for upregulating PGRN expression in human neurons and thus may have translational relevance in neurodegenerative disease. 31330099 2019
CUI: C0549473
Disease: Thyroid carcinoma
Thyroid carcinoma
0.010 Biomarker disease BEFREE HDAC1 and HDAC2 Double Knockout Triggers Cell Apoptosis in Advanced Thyroid Cancer. 30669676 2019
CUI: C0740447
Disease: Diabetic peripheral neuropathy
Diabetic peripheral neuropathy
0.010 Biomarker disease BEFREE STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy. 30913399 2019
CUI: C0751651
Disease: Mitochondrial Diseases
Mitochondrial Diseases
0.010 Biomarker group BEFREE The present results suggest that the inhibition of HDAC1 suppresses the pathogenic processes that lead to the degeneration of motoneurons in mitochondrial diseases. 31614134 2019
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder
0.010 AlteredExpression phenotype BEFREE We have recently shown in a zebrafish model of LPC-driven liver regeneration that inhibition of Hdac1 activity through MS-275 treatment enhances <i>sox9b</i> expression in LPCs and impairs LPC-to-hepatocyte differentiation. 30992706 2019
CUI: C1336745
Disease: Thymic Lymphoma
Thymic Lymphoma
0.010 Biomarker disease BEFREE Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma. 31304633 2019
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis
0.010 AlteredExpression disease BEFREE Our results showed that ellagic acid significantly reduced protein expression of HDAC1, mRNA expression of collagen I, collagen III, MMP-2 and MMP-9 and the area of cardiac fibrosis in MI rats. 31168029 2019
CUI: C1623038
Disease: Cirrhosis
Cirrhosis
0.010 AlteredExpression disease BEFREE HDAC1 was expressed in reactive ducts and hepatocyte buds of liver tissues from patients with cirrhosis. 30267710 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.010 Biomarker disease BEFREE In conclusion, our results indicated that RFX1 expression deficiency in CD14+ monocytes from CAD patients contributed to MCP1 overexpression <i>via</i> a deficiency of recruitments of HDAC1 and SUV39H1 in the <i>MCP1</i> promoter, which highlighted the vital role of RFX1 in the pathogenesis of CAD. 31737059 2019
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.010 AlteredExpression disease BEFREE We identified 2 genes, histone deacetylase 1 (HDAC1) and HDAC2, contributing to the pathogenesis of proteinuric kidney diseases, the leading cause of end-stage kidney disease. mRNA expression profiling from proteinuric mouse glomeruli was linked to Connectivity Map databases, identifying HDAC1 and HDAC2 with the differentially expressed gene set reversible by HDAC inhibitors. 30776024 2019
Human immunodeficiency virus (HIV) II infection category B1
0.010 Biomarker disease BEFREE RBBP4 binds to the HIV-1 long terminal repeat (LTR), represses HIV-1 LTR-mediated transcription through recruiting nuclear receptor subfamily 2 group F member 1(NR2F1) and histone deacetylase 1 and 2 (HDAC1/2) to HIV-1 LTR, and further controls local histone 3 (H3) deacetylation and chromatin compaction. 31435636 2019
CUI: C4721806
Disease: Carcinoma, Basal Cell
Carcinoma, Basal Cell
0.010 Biomarker disease BEFREE The GLI1 transcription factor must maintain maximal Hedgehog pathway output in basal cell carcinomas (BCCs), and we have previously shown that resistant BCCs increase GLI1 deacetylation through atypical protein kinase Cι/λ (aPKC) and HDAC1. 30503211 2019
CUI: C0001956
Disease: Alcohol Use Disorder
Alcohol Use Disorder
0.010 Biomarker disease BEFREE Our study demonstrated that a new compound designed to target HDAC-1 is effective in reducing ethanol intake and relapse in rats and further confirm the interest of pursuing research to study the exact mechanism by which such inhibitor may be useful to treat AUDs. 29713786 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.010 AlteredExpression group BEFREE Combined inhibition of HDAC1/2 and Brd4 resolved the aberrant ISG expression detected in cells derived from patients with two inherited interferonopathies, ISG15 and USP18 deficiencies, defining a novel therapeutic approach to ISG-associated autoimmune diseases. 30463877 2018
CUI: C0005699
Disease: Blast Phase
Blast Phase
0.010 AlteredExpression disease BEFREE Patients in accelerated phase CML (CML-AP) and blast phase CML (CML-BP) showed lower expressions of MEG3 and miR-147 and higher expressions of DNMT1, DNMT3B, MBD2, MECP2 and HDAC1 compared to the controls. 30072211 2018
CUI: C0006111
Disease: Brain Diseases
Brain Diseases
0.010 Biomarker group BEFREE Histone deacetylase 1 (HDAC1) plays important roles in self-renewal of stem cells as well as the recovery of brain disorders. 30662396 2018
CUI: C0007130
Disease: Mucinous Adenocarcinoma
Mucinous Adenocarcinoma
0.010 AlteredExpression disease BEFREE Overexpression of HDAC1 was detected in the nucleus of all cases with MUC, followed by CCC (80%), SEC (73%), and EMC (53%). 29456726 2018
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.010 Biomarker disease BEFREE TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia. 29896413 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.010 AlteredExpression disease BEFREE VPA could induce CHD (P < 0.001) and inhibit mRNA or protein expression of Hdac1/2/3 as well as Vangl2/Scrib in fetal hearts, in association with total Hdac activity repression (all P < 0.05). 30127218 2018
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis
0.010 Biomarker disease BEFREE Our data demonstrate a novel pathophysiological role for HDAC1 in EAE and provide evidence that selective inhibition of HDAC1 might be a promising strategy for the treatment of MS. 28964722 2018
Leukemia, Myeloid, Accelerated Phase
0.010 AlteredExpression disease BEFREE Patients in accelerated phase CML (CML-AP) and blast phase CML (CML-BP) showed lower expressions of MEG3 and miR-147 and higher expressions of DNMT1, DNMT3B, MBD2, MECP2 and HDAC1 compared to the controls. 30072211 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.010 Biomarker disease BEFREE Our data demonstrate a novel pathophysiological role for HDAC1 in EAE and provide evidence that selective inhibition of HDAC1 might be a promising strategy for the treatment of MS. 28964722 2018
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus
0.010 Biomarker disease BEFREE The coimmunoprecipitation assay revealed that the interaction between yin yang 1 and histone deacetylase 1 in the cortex and hippocampus was enhanced during SE, indicating that this interaction is also responsible for the CYP2D4 suppression. 29175413 2018
CUI: C0206701
Disease: Cystadenocarcinoma, Serous
Cystadenocarcinoma, Serous
0.010 AlteredExpression disease BEFREE HDAC1 nuclear expression adversely affected overall survival in SEC (P=0.02) and EMC (P=0.03), and HDAC7 cytoplasmic expression in CCC was associated with a poor prognosis (P=0.06). 29456726 2018
CUI: C0235964
Disease: Renal dysgenesis
Renal dysgenesis
0.010 GeneticVariation disease BEFREE Finally, although HDAC1/2-deficient NPCs and RVs overexpress hyperacetylated p53, <i>Trp53</i> deletion failed to rescue the renal dysgenesis. 29712641 2018