Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.010 AlteredExpression disease BEFREE In summary, our study demonstrates that LPS- and TNF-α-induced NF-κBp50-HDAC1 interaction represses BAMBI transcriptional activity, which contributes to TLR4-mediated enhancement of TGF-β signaling in HSCs during liver fibrosis. 24448807 2014
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.010 Biomarker disease BEFREE By interaction with HDAC1, phospho-SATB1 contributes to the invasive and proliferative phenotype of GBM cells. 24176859 2014
Childhood Acute Lymphoblastic Leukemia
0.010 AlteredExpression disease BEFREE Expression of HDAC1-11 was determined in 93 primary ALL and eight healthy donor samples. 23948281 2013
Squamous cell carcinoma of the head and neck
0.010 Biomarker disease BEFREE Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma. 23558898 2013
CUI: C0006012
Disease: Borderline Personality Disorder
Borderline Personality Disorder
0.010 AlteredExpression disease BEFREE In parallel, a significant co-variation of HDAC1 with GABRB2 expression observed in CON remained significant in BPD but not in SCZ; comparably, a significant co-variation of HDAC2 with GABRB2 expression observed in CON became non-significant in both SCZ and BPD. 22206711 2012
CUI: C0006287
Disease: Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
0.010 AlteredExpression disease BEFREE In parallel, a significant co-variation of HDAC1 with GABRB2 expression observed in CON remained significant in BPD but not in SCZ; comparably, a significant co-variation of HDAC2 with GABRB2 expression observed in CON became non-significant in both SCZ and BPD. 22206711 2012
CUI: C0205824
Disease: Liposarcoma, Dedifferentiated
Liposarcoma, Dedifferentiated
0.010 GeneticVariation disease BEFREE While the point mutation rate was modest, integrative analyses and additional screening identified somatic mutations in HDAC1 in 8.3% of DLPS. 22328974 2012
CUI: C0265286
Disease: Dyggve-Melchior-Clausen syndrome
Dyggve-Melchior-Clausen syndrome
0.010 Biomarker disease BEFREE After DMC treatment NF-κB co-immunoprecipitated with HDAC1. 21983014 2012
CUI: C0345905
Disease: Intrahepatic Cholangiocarcinoma
Intrahepatic Cholangiocarcinoma
0.010 AlteredExpression disease BEFREE These findings suggested that HDAC1 positive expression was a potential new prognostic indicator of IHCC, and a possible promising molecular target through the regulation of HIF-1α. 21982637 2012
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis
0.010 AlteredExpression disease BEFREE Recently, HDAC1 has been reported to be overexpressed in hepatocellular carcinoma (HCC), but its biological roles in hepatocarcinogenesis remain to be elucidated. 22496786 2012
CUI: C3888194
Disease: MIXED LINEAGE LEUKEMIA
MIXED LINEAGE LEUKEMIA
0.010 GeneticVariation disease BEFREE These changes were accompanied by increased p300 (EP300), histone deacetylase 1 (HDAC1), myeloid/lymphoid or mixed lineage leukemia (MLL), SET7/9 (SETD7), G9A (EHMT2), JMJD2C (KDM4C) and JARID1A (KDM5A) expression, as well as reduced HDAC2, HDAC7, LSD1 (KDM1A), JMJD2A (KDM4A) and JMJD2B (KDM4B) expression. 21936853 2012
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic
0.010 AlteredExpression disease BEFREE Regulatory factor X-box 1 (RFX1) can interact with DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1), and RFX1 down-regulation contributes to DNA hypomethylation and histone H3 hyperacetylation at the cluster of differentiation (CD) 11a and CD70 promoters in CD4(+) T cells of patients with systemic lupus erythematosus (SLE). 21192791 2011
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.010 AlteredExpression disease BEFREE Our results showed nuclear HDAC activity and expression of HDAC1 were significantly higher in RA than in OA synovial tissues, and they were upregulated by TNFα stimulation in RASFs. 20609223 2011
CUI: C0220621
Disease: Childhood Acute Myeloid Leukemia
Childhood Acute Myeloid Leukemia
0.010 AlteredExpression disease BEFREE Treatments with structurally diverse HDACIs and HDAC shRNA knockdown experiments revealed that down-regulation of both HDACs 1 and 6 is critical in enhancing cytarabine-induced apoptosis in pediatric AML, at least partly mediated by Bim. 21359182 2011
CUI: C0521158
Disease: Recurrent tumor
Recurrent tumor
0.010 GeneticVariation phenotype BEFREE Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. 20731616 2011
CUI: C0936223
Disease: Metastatic Prostate Carcinoma
Metastatic Prostate Carcinoma
0.010 Biomarker disease BEFREE Interestingly, HDAC1 association with Sp1 and with the P-Rex1 promoter were much weaker in metastatic prostate cancer PC-3 cells than in non-metastatic prostate cancer cells, and HDAC inhibitors only had very modest stimulatory effects on P-Rex1 promoter activity and P-Rex1 expression in PC-3 cells. 21636851 2011
Metastasis from malignant tumor of prostate
0.010 Biomarker disease BEFREE Interestingly, HDAC1 association with Sp1 and with the P-Rex1 promoter were much weaker in metastatic prostate cancer PC-3 cells than in non-metastatic prostate cancer cells, and HDAC inhibitors only had very modest stimulatory effects on P-Rex1 promoter activity and P-Rex1 expression in PC-3 cells. 21636851 2011
CUI: C1879828
Disease: Benign Teratoma
Benign Teratoma
0.010 Biomarker disease BEFREE These findings reveal a novel role for HDAC1 in the control of tumour proliferation and identify HDAC1 as potential marker for benign teratomas. 20967026 2011
CUI: C0004135
Disease: Ataxia Telangiectasia
Ataxia Telangiectasia
0.010 AlteredExpression disease BEFREE We show that HDACs 1 and 2 are overexpressed in ATCs compared with normal cells or benign tumors and that HDAC inhibitors induce apoptosis selectively in the fully transformed thyroid cells. 19802013 2010
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease
0.010 AlteredExpression disease BEFREE In addition, decreased HDAC1 expression is accompanied by worse outcome in HL. 20415600 2010
CUI: C0235782
Disease: Gallbladder Carcinoma
Gallbladder Carcinoma
0.010 AlteredExpression disease BEFREE This pattern was verified in cultured cells; EZH2 was highly expressed only in TGBC2TKB, whereas HDAC1/2 were expressed in HGECs and TGBC2TKB. 19860841 2010
CUI: C0032927
Disease: Precancerous Conditions
Precancerous Conditions
0.010 Biomarker group BEFREE Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells. 19384952 2009
Prostatic Intraepithelial Neoplasias
0.010 AlteredExpression disease BEFREE Our data indicate that MCP30 selectively induces PIN and PCa apoptosis and inhibits HDAC-1 activity. 19384952 2009
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 Biomarker phenotype LHGDN CK2 may be a key mediator for HDAC1 and HDAC2 activation under hypoxia in tumor cells 17935135 2008
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms
0.010 Biomarker group LHGDN class I HDACs suggest that these targets should be explored as predictive factors in ovarian and endometrial carcinomas prospectively. 18714364 2008