HDAC1, histone deacetylase 1, 3065

N. diseases: 277; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease BEFREE Our data suggest that HDAC1 inhibition should be considered as a therapeutic approach to treat schizophrenia. 28533418 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 AlteredExpression disease BEFREE We used >700 well-characterized samples from patients diagnosed with schizophrenia (n = 175), major depressive disorder (n = 135), and bipolar disorder (n = 61) to measure HDAC1 and HDAC2 transcript levels by quantitative real-time PCR in dorsolateral prefrontal cortex (DLPFC) and caudate compared to control samples. 27959513 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 AlteredExpression disease BEFREE Several of the genes in this network including epigenetic factors histone deacetylase 1 (HDAC1) and death-associated protein 6 (DAXX), the GABAergic enzyme GAD65 as well as the kainate receptor (KAR) subunits GluR6 and 7 show significant changes in expression in this area in SZ. 27733539 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease BEFREE To characterize the contribution of these factors to the developmental perturbation hypothesized to underlie SZ, lentiviral vectors carrying short hairpin RNA interference (shRNAi) for HDAC1 and DAXX were used. 26812044 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease PSYGENET Postmortem brain studies have shown that HDAC1-a lysine deacetylase with broad activity against histones and nonhistone proteins-is frequently expressed at increased levels in prefrontal cortex (PFC) of subjects diagnosed with schizophrenia and related disease. 23664640 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 AlteredExpression disease BEFREE In summary, we suggest that reduced p35 expression in schizophrenia has an impact on synaptic protein expression and cognition and that these deficits can be rescued, at least in part, by the inhibition of histone deacetylase 1. 21772061 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 AlteredExpression disease BEFREE The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. 17961987 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 AlteredExpression disease LHGDN The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. 17961987 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.360 Biomarker disease PSYGENET The mRNA expression level of an epigenetically regulated schizophrenia candidate gene GAD67 was strongly and negatively correlated with the mRNA expression levels of HDAC1, HDAC3 and HDAC4 levels. 17961987 2008