HFE, homeostatic iron regulator, 3077

N. diseases: 415; N. variants: 59
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Our results clearly demonstrate that the HFE genotype impacts the expression of tyrosine hydroxylase in the substantia nigra, the gut microbiome and the response to paraquat providing additional support that the HFE genotype is a disease modifier for Parkinson's disease. 29315562 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE The meta-analysis indicated that C282Y and H63D polymorphisms in the HFE gene might not be associated with PD. 26340960 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE The association between the C282Y and H63D polymorphisms of HFE gene and the risk of Parkinson's disease: A meta-analysis. 25863172 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE We examined four known polymorphisms, C282Y and H63D in the HFE gene, G258S in the TF gene and S82G in the TFR gene, in 181 sporadic PD patients and 180 controls from Southern Italy to investigate their possible role in susceptibility to PD. 21384276 2011
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease BEFREE Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands. 18300942 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE We conclude that in the Italian population, the most common HFE mutations, H63D and C282Y are not associated with the individual risk to develop PD, nor have specific influence on the clinical features of the disease. 18325820 2008
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE This study does not indicate increased susceptibility to Parkinson's disease in HFE gene mutation carriers in Norway. 17056630 2007
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 Biomarker disease CTD_human Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort. 16824219 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Our results indicate that mutations in the HFE gene are not a common cause for PD with increased iron levels of the SN. 16935420 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort. 16824219 2006
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease BEFREE We studied the role of mutations in the hemochromatosis gene HFE in PD and other parkinsonism (non-PD PS) in two population-based series. 12902032 2003
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.400 GeneticVariation disease LHGDN The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients. 12098643 2002