HFE, homeostatic iron regulator, 3077

N. diseases: 415; N. variants: 59
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.320 GeneticVariation disease BEFREE In Caucasians, C282Y HFE homozygotes are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, due to alcohol abuse or concurrent genetic modifiers that are now being identified. 26164493 2015
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.320 Biomarker disease PSYGENET Unlike these rare instances, in white people, homozygotes for C282Y polymorphism in HFE are numerous, but they are only predisposed to hemochromatosis; complete organ disease develops in a minority, when these individuals abuse alcohol or from other unidentified modifying factors. 20542038 2010
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse
0.320 GeneticVariation disease BEFREE These patients differed from patients without PCT in that they were men, past history of alcohol abuse and HFE gene mutations were more common and the source of infection was almost always unknown. 12737448 2003