HGF, hepatocyte growth factor, 3082

N. diseases: 671; N. variants: 22
Disease: Neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.360 AlteredExpression disease BEFREE The neuroblastoma SK-N-SH cells with HGF overexpression which activates MET signalling are sensitive to MET inhibitors. 31137515 2019
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.360 Biomarker disease BEFREE Activation of the HGF-mediated MET pathway is involved in escape to selective VEGFR inhibition in neuroblastoma suggesting combined inhibition of MET and VEGFR signaling to reduce secondary resistance and enhanced invasiveness. 27922668 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.360 Biomarker disease BEFREE This study showed that concentrations of HGF and S-VEGF-A are elevated in patients with NB. 19661350 2009
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.360 AlteredExpression disease BEFREE We show that sublethal doses of irradiation up-regulated the expression of the hepatocyte growth factor (HGF) and its receptor c-Met in some neuroblastoma cell lines. 15809092 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.360 AlteredExpression disease BEFREE We conclude that TrkB expression in neuroblastoma cells results in an increase in their invasive capability via upregulated expression of HGF/c-Met and enhanced activity of proteolytic networks. 16051641 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.360 Biomarker disease CTD_human The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness. 16051641 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.360 Biomarker disease BEFREE We show that HGF stimulates invasion of neuroblastoma cells in vitro and in vivo, and it promotes the formation of angiogenic neuroblastomas in vivo. 15342394 2004