<i>Conclusions</i>: Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (<i>DC-SIGN</i>) promoter-336G/A (<i>rs4804803</i>) polymorphism is association with severe dengue, and it acts in different directions for Asians and South-central Americans.
A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF).
We demonstrated that the TT genotype of CLEC5A SNP (rs1285933 C>T) is associated with dengue severity (OR=2.25; p=0.03) and that GG genotype of -336G>A DCSIGN (CD209) SNP is associated with protection to severe dengue (OR=0.12; p=0.04).
These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever.