|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we explored DC-specific-ICAM3-grabbing-nonintegrin (DC-SIGN) targeting as a potential vaccine against tuberculosis.
|
29662482 |
2018 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study provides evidence of an association between CD209 and CD209L polymorphisms and TB development in a Brazilian population, suggesting that variations in these genes may influence the protection and susceptibility to infection caused by M. tuberculosis.
|
24874302 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between -336 A/G polymorphism of CD209 and susceptibility to/protection from tuberculosis is inconsistent.
|
23751770 |
2014 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis suggested that CD209 promoter polymorphisms (-336A/G, -871A/G) were unlikely to substantially contribute to TB susceptibility.
|
22911807 |
2012 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in human leukocyte antigen (HLA), MBL2, CD209, vitamin D receptor, cytokine, chemokine and chemokine receptor genes have been shown to be associated with development of TB in HIV patients.
|
21943869 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis has indicated that the CD209-336A/G polymorphism may not contribute to susceptibility to TB.
|
22553928 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The 101 paired DNA samples from patients with pulmonary TB (human and M. tuberculosis DNA) were studied by 12-loci MIRU-VNTR typing (M. tuberculosis strains) and CD209 -336 A/G typing (human DNA).
|
22027159 |
2012 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further extensive studies are required to confirm the contribution of CD209 polymorphisms to TB susceptibility.
|
21704100 |
2011 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that the 2 promoter variants of DC-SIGN gene were not associated with susceptibility to tuberculosis in Chinese.
|
21081145 |
2011 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) -336A>G in the CD209 promoter has been demonstrated to regulate promoter activity and to be associated with several important infectious diseases, such as human immunodeficiency virus-1 (HIV-1), Mycobacterium tuberculosis, and Dengue fever.
|
20359516 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of tuberculosis and dengue fever.
|
20470843 |
2010 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CCR2 V64I (G/A), monocyte chemoattractant protein-1 (MCP-1) -2518 A/G, stromal cell derived factor-1alpha; (SDF-1alpha) 3'UTR G/A and DC-SIGN gene polymorphisms were studied by polymerase chain reaction based methods in HIV-1 infected patients without TB (n=151), with pulmonary TB (PTB) (n=81) and extrapulmonary TB (n=31), 155 PTB patients without HIV and 206 healthy controls.
|
19942750 |
2009 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study we investigated whether variants in the DC-SIGN encoding CD209 gene are associated with susceptibility to or protection against HIV-1 infection as well as development of tuberculosis (TB) among HIV-1 infected south Indian patients.
|
19126442 |
2009 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
This study finds that the CD209 -336G variant allele is associated with significant protection against tuberculosis in individuals from sub-Saharan Africa and, furthermore, cases with -336GG were significantly less likely to develop tuberculosis-induced lung cavitation.
|
18167547 |
2008 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study finds that the CD209 -336G variant allele is associated with significant protection against tuberculosis in individuals from sub-Saharan Africa and, furthermore, cases with -336GG were significantly less likely to develop tuberculosis-induced lung cavitation.
|
18167547 |
2008 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this light, we aimed to study the potential implication of DC-SIGN genetic variation in the predisposition to tuberculosis in a group of Tunisian patients.
|
18082570 |
2007 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In this light, we aimed to study the potential implication of DC-SIGN genetic variation in the predisposition to tuberculosis in a group of Tunisian patients.
|
18082570 |
2007 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB.
|
17462920 |
2007 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Analysis of DC-SIGN (CD209) functional variants in patients with tuberculosis.
|
17055357 |
2006 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After exclusion of significant population stratification in our cohort, we observed an association between two CD209 promoter variants (-871G and -336A) and decreased risk of developing tuberculosis.
|
16379498 |
2006 |