Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α).
|
29959560 |
2018 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α-induced pro-angiogenic factor.
|
29532562 |
2018 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Oncostatin M upregulates HIF-1α in breast tumor associated macrophages independent of intracellular oxygen concentration.
|
29246543 |
2018 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here, we showed that the epigenetic reader zinc finger MYND-type containing 8 (ZMYND8) is induced by HIF-1 and HIF-2 in breast cancer cells and also upregulated in human breast tumors, and is correlated with poor survival of patients with breast cancer.
|
29629903 |
2018 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
|
29180628 |
2017 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We hypothesize that inhibitors of HIF-1α or the proteasome might stabilize ER-α expression in breast tumors in vivo, and work in combination with endocrine therapies to reduce resistance.
|
28320353 |
2017 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Intratumoral hypoxia may explain elevated CA in vivo because exposure of cultured cells to hypoxia or mimicking hypoxia pharmacologically or genetically increases CA, and HIF-1α and hypoxic gene signature expression correlate with CA and centrosomal gene signature expression in breast tumors.
|
28272508 |
2017 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
GPER is a transcriptional target of hypoxia inducible factor 1 alpha (HIF-1α) and activates VEGF expression and angiogenesis in hypoxic breast tumor microenvironment.
|
29212519 |
2017 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study demonstrates that HIF-1α is involved in the transcriptional regulation of the TFPI gene, and suggests that a hypoxic microenvironment inside a breast tumor may induce a procoagulant state in breast cancer patients.
|
26598923 |
2016 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription.
|
26287601 |
2015 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Last, clinically relevant correlations between miR-18a, HIF1A, hypoxia-responsive gene expression and distant metastasis-free survival (DMFS) were assessed using published expression array breast tumors data sets.
|
25069832 |
2014 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1α-mediated VEGF-dependent angiogenesis.
|
23728336 |
2014 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study is the first to identify HIF-1α as a modulator of PII-driven aromatase expression in human breast tumor-associated stroma and provides a novel mechanism for estrogen regulation in obesity-related, post-menopausal breast cancer.
|
23566437 |
2013 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α.
|
24349381 |
2013 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
At 73/74 wk, both modes of calorie restriction lowered IGF-I protein expression levels and Akt activation in MTs and mammary fat pads, and CCR increased mTOR, p70S6K, p4EBP1, and HIF-1 expression.
|
21462085 |
2011 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We hypothesised that either somatic mutation or hypermethylation of the CITED4 gene underlies CITED4 down-regulation and thus enhanced HIF-1α expression in some breast tumours.
|
21755341 |
2011 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition, we have found that factor 26 (1q CNA) is negatively correlated with HIF-1alpha protein and hypoxia pathways in breast tumors and cell lines.
|
20824128 |
2010 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.
|
17805961 |
2008 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer.
|
18949419 |
2008 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Extracellular matrix and HIF-1 signaling: the role of prolidase.
|
17999410 |
2008 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha.
|
17653093 |
2008 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues.
|
18563339 |
2008 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women.
|
18160046 |
2008 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Single nucleotide polymorphisms in the hypoxia-inducible factor-1alpha (HIF-1alpha) gene in human sporadic breast cancer.
|
18279708 |
2008 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.
|
18030615 |
2008 |