|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-B*52 is an established susceptibility locus to TAK.
|
30498034 |
2018 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis.
|
30498034 |
2018 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variants in the human leukocyte antigen-B/MICA and Takayasu arteritis in Chinese Han population.
|
28261975 |
2018 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The genetic susceptibility with HLA-B*52, as well as additional classical alleles and loci, implicate both HLA class I and class II involvement in TAK.
|
28756073 |
2017 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the genetic comparison of HLA class I between TA patients with IBD and those without IBD, HLA-B*52:01 and C*12:02 were more frequent in the IBD-TA group (P = 0.001 and P = 0.009, respectively).
|
28449344 |
2017 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-B*52:01-C*12:02, which is found in approximately 20% of all Japanese persons, is well known to be associated with ulcerative colitis and Takayasu arteritis.
|
28968792 |
2017 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrated that the HLA-B*52 allele and TNF-α-308 A/G polymorphism may contribute to TA susceptibility.
|
27815653 |
2017 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-B*67:01 is a novel susceptibility HLA-B allele to TAK confirmed in the Japanese population.
|
26178430 |
2016 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Since TAK and UC share HLA-B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK.
|
25931203 |
2015 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
|
25604533 |
2015 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-B*52:01 and *67:01 are susceptibility alleles to TAK, and the 171st and 67th amino acid residues of HLA-B protein are suggested important for TAK susceptibility.
|
24548718 |
2014 |
|
Takayasu Arteritis
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
The prevalence and characteristics of microalbuminuria in the general population: a cross-sectional study.
|
23830507 |
2013 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-B 67:01 is associated with TAK independently from HLA-B 52:01.
|
23873822 |
2013 |
|
Takayasu Arteritis
|
0.500 |
SusceptibilityMutation
|
disease |
ORPHANET |
Our findings indicate that IL12B plays a fundamental role on the pathophysiology of TAK in combination with HLA-B(∗)52:01 and that common autoimmune mechanisms underlie the pathology of TAK and other autoimmune disorders such as psoriasis and inflammatory bowel diseases in which IL12B is involved as a genetic predisposing factor.
|
23830516 |
2013 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is supported by the genetic association with HLA-B*52.
|
23830517 |
2013 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that IL12B plays a fundamental role on the pathophysiology of TAK in combination with HLA-B(∗)52:01 and that common autoimmune mechanisms underlie the pathology of TAK and other autoimmune disorders such as psoriasis and inflammatory bowel diseases in which IL12B is involved as a genetic predisposing factor.
|
23830516 |
2013 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences.
|
22309845 |
2012 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This preliminary study suggests a difference in the distribution of the residues 63 and 67 of the HLA-B alleles in patients with TA and TB.
|
18646257 |
2008 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
LHGDN |
This preliminary study suggests a difference in the distribution of the residues 63 and 67 of the HLA-B alleles in patients with TA and TB.
|
18646257 |
2008 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the aim of the present study was to analyze the distribution of HLA-B alleles in TA (n = 40) and Tb (n = 34) patients and healthy controls (72 exposed and 99 nonexposed).
|
17462513 |
2007 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
In spite of the loose clinical relationship between TA and Tb, we did not detected any genetic relationship between them when the HLA-B alleles were analyzed in these groups of patients.
|
17462513 |
2007 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Studies both in Mexican and Asian populations suggest that residues at positions 63 (glutamic acid) and 67 (serine) of the HLA-B molecule could be the genetic markers for TA.
|
15585327 |
2005 |
|
Takayasu Arteritis
|
0.500 |
Biomarker
|
disease |
LHGDN |
In the present work, we analyzed the sequence of HLA-B alleles in 26 TA patients and 62 healthy controls.
|
15585327 |
2005 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We studied HLA-B alleles of 12 Mexican patients with TA using PCR-SSP and sequencing.
|
10980349 |
2000 |
|
Takayasu Arteritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Combined analyses of polymorphisms in the HLA-B and MICA genes with those in the microsatellites suggest that there are two different disease-susceptible loci for Takayasu's arteritis; one is mapped near the C1-2-A locus and the other is more closely linked to the HLA-B gene than to the MICA gene, because there are at least two different disease-associated HLA-B haplotypes, HLA-B*52 and -B*39.2 haplotypes, in which the disease-associated C1-2-A allele is shared in common.
|
10980346 |
2000 |