|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule and HLA DQA1*03 and DQB1*03 alleles encoding DQ8 molecules are strongly associated with celiac disease (CD) and type 1 diabetes (T1D), two common autoimmune diseases (AD).
|
31331105 |
2019 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Because of rarely reported cases of CD/rhabdomyolysis, anti-tissue transglutaminase (tTG) antibodies were measured and found positive (IgA 34 U/mL, unv <9).HLA typing was DQA1 05:02, DQB1 03:02.
|
28606713 |
2018 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We have developed and validated CD-loop-mediated isothermal amplification (CD-LAMP), a LAMP assay, which enables rapid identification of the signature CD risk genotypes, HLA-DQ2.5, HLA-DQ8, HLA-DQ2.2, and HLA-DQA1*05.
|
29458095 |
2018 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The data also revealed 2 distinct celiac disease risk DR3-DQA1*05:01-DQB*02:01 haplotypes distinguished by either the DRB3*01:01:02 or DRB3*02:02:01 alleles, indicating that different DRB1*03:01-DQB1*02:01 haplotypes confer different risk for celiac disease.
|
28585303 |
2017 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The DRB1 *03:01- DQB1 *02:01- DQA1 *05:01/ DRB1 *04- DQB1 *03:02- DQA1 *03 haplotype combination, encoding DQ2.5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%).
|
28247576 |
2017 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
One patient showed a positivity only for HLA-DQ2.2 (encoded by DQA1*02 & B1*02).Our study showed that the genetic risk for CD was present in more than one-third of the cases without a confirmed diagnosis of CD.
|
28514313 |
2017 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Celiac disease (CD) is associated with tissue transglutaminase autoantibodies (tTGAs) in individuals carrying the human leukocyte antigen (HLA) risk haplotypes DQA1*05:01-DQB1*02:01 (DQ2) and/or DQA1*03:01-DQB1*03:02 (DQ8).
|
26301618 |
2016 |
|
Celiac Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrated that HLA DQA1*05 and DQB1*02 gene expression is much higher than expression of non-CD-associated genes.
|
27083396 |
2016 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In patients with LADA similarly to type 1 genotype DQA1*0301 seems to CONFER susceptibility to thyroid autoimmunity, and DQB1*0201 to celiac disease.
|
26884287 |
2016 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We like to suggest that the haplotype HLA-DQA1*03-DQB1*03:03 (HLA-DQ9.3), which is common in Chinese, is a new susceptibility factor for CD in China.
|
26496305 |
2015 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four modified sequence specific primers (SSP) pairs were designed for the selective amplification of coeliac disease associated alleles (DQA1*05, DQB1*02, DQB1*03:02 alleles), and human growth hormone (positive control).
|
26043316 |
2015 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Associations of HLA-DR3-DQA1*05:01-DQB1*02:01 (i.e., DR3-DQ2) and, to a lesser extent, DR4-DQA1*03:01-DQB1*03:02 (i.e., DR4-DQ8) with the risk of CD differ by country, consistent with additional genetic heterogeneity that further refines risk.
|
26010309 |
2015 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this chapter we will present the principal technical methods to genotype the HLA-DQA1* and -DQB1* alleles associated with celiac disease (CD), corresponding to the serological heterodimers HLA-DQ2 and -DQ8.
|
26498615 |
2015 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As expected, all CD patients had at least one of the CD-associated alleles, and the highest CD risk was indicated by the presence of the HLA-DQ2.5 heterodimer (HLA-DQA1*05-DQB1*02) with HLA-DQB1*02 in homozygosity.
|
25413104 |
2014 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we aimed to evaluate the frequency of polymorphisms that affects the structure of the enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), with levels being dependent on the amount of oxidative stress and whether or not there is an association with the mutations DQA1*0501, DQB1*0201, and DRB1*04 that are frequently reported for CD.
|
24634124 |
2014 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To predict the HLA-DQA1 and -DQB1 genes, we used six previously reported HLA-tagging single nucleotide polymorphism to determine HLA genotypes in 59 Iranian patients with 'biopsy-confirmed' CD and in 151 healthy Iranian individuals.
|
24876751 |
2014 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
celiac disease is associated with the HLA class II alleles: DQA1*05-DQB1*02 and DQB1*0302.
|
24274444 |
2013 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For the development of classic gluten-sensitive CD a certain HLA haplotype involving the loci DQA1* and DQB1* and encoding two different HLA DQ heterodimers is the prerequisite.
|
23609110 |
2013 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The risk for celiac disease (CD) is clearly related to specific HLA DQA1 and DQB1 alleles, but HLA -typing is often considered too costly for frequent use.Here we present a method using sequence-specific primed PCR (PCR-SSP) for HLA-DR-DQ genotyping optimized for capillary electrophoresis on Applied Biosystems 3130xl Genetic Analyzer.
|
22976110 |
2013 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Patients with celiac disease (CD) lacking both human leukocyte antigen (HLA)-DQ2.5 in cis (DQA1*05:01, DQB1*02:01) or trans (DQA1*05:05, DQB1*02:02) configuration and HLA-DQ8 (DQA1*03:01, DQB1*03:02) are considered to be rare.
|
23085892 |
2013 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Less frequently, CD occurs in individuals positive for the DQ2.x heterodimers (DQA1≠*05 and DQB1*02) and very rarely in patients negative for these DQ predisposing markers.
|
23050549 |
2012 |
|
Celiac Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
HLA-DQA1 and DQB1 molecular typing was performed in 218 adult CD patients (169 with uncomplicated CD, 27 with complicated CD, and 22 with potential CD) and 224 healthy stem cell donors.
|
21694611 |
2012 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study confirms the existing data and provides additional evidence supporting a strong genetic predisposition for CD associated with the class II alleles DQB1*02 and DQA1*05 encoding the serological specificity DQ2.
|
23041663 |
2012 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively reviewed the medical records of 127 consecutive cases of adult-onset celiac disease evaluated at a single United States center to determine the distribution of the associated human leukocyte antigen DQA1 and DQB1 alleles.
|
21292306 |
2011 |
|
Celiac Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the association with CD became stronger when B*08(B*08-DQA*0501-DQB1*0201-DRB1*0301, P = 5.07 x 10(-12)) was present in the DRB1*0301-DQB1*0201-DQA1*0501 (P = 5.00 x 10(-10)) extended haplotype.
|
20492597 |
2010 |