Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The Montecarlo Exact Fisher Test demonstrated marked differences in all three Loci, DQA1, DQB1, DRB1 (p<0.0001) between AP versus both AITD and controls, as well as between AP type II (Addison's disease as major endocrine component) and AP type III (T1D + AITD). 31675055 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The heterozygous DQ2/8 (DQA1*05:01-DQB1*02:01/DQA1*03:01-DQB1*03:02) genotype confers the highest risk in type 1 diabetes (T1D), whereas the DQ6/8 (DQA1*02:01-DQB1*06:02/DQA1*03:01-DQB1*03:02) genotype is protective. 30626607 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE A strong positive association of DRB1*04-DQA1*0301-DQBl*0302 (OR=5.67, p<0.001) and DRB1*0301-DQA1*0501-DQB1*0201 (OR=6.24, p<0.001) putative haplotypes with IDDM was evident in Jordanian IDDM patients whereas DRB1*1101-DQA1*0505- DQB1*0301 (OR=0.23, p=0.03) was shown to have a protective role against T1D in Jordanians. 31742498 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE HLA DQA1*05 and DQB1*02 alleles encoding the DQ2.5 molecule and HLA DQA1*03 and DQB1*03 alleles encoding DQ8 molecules are strongly associated with celiac disease (CD) and type 1 diabetes (T1D), two common autoimmune diseases (AD). 31331105 2019
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE By examining the epigenetic methylation maps of cord blood samples, we found marked differences in the methylation status of CpG sites within the MHC genes (cis-metQTLs) between carriers of the type 1 diabetes risk haplotypes HLA-DRB1*03-DQA1*0501-DQB1*0201 (DR3-DQ2) and HLA-DRB1*04-DQA1*0301-DQB1*0302 (DR4-DQ8). 29224923 2018
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The association of DR4/DR8 heterozygous genotype suggested the pathologic importance of trans-complementing DQα-β heterodimer molecules encoded by DQA1 allele of one haplotype and the DQB1 allele of the other haplotype, as it was proposed in the HLA association studies of Type 1 diabetes. 29088299 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Participants were aged 1-24 years.T1D was significantly associated with DR3, DQA1∗05:01, DQB1∗02:01, and DR3-DR4. 28808665 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The DRB1 *03:01- DQB1 *02:01- DQA1 *05:01/ DRB1 *04- DQB1 *03:02- DQA1 *03 haplotype combination, encoding DQ2.5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%). 28247576 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Genotypes generated by the association of markers Arg52 DQA1 positive and Asp57 DQB1 negative increase T1D susceptibility much more than one would expected by a simple additive effect of those markers separately (OR = 26.9). 28834219 2017
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE In addition to confirming known associations, a systemic lupus erythematosus-associated risk variant at TNXB was also associated with CKD attributed to type 1 diabetes (p = 2.5 × 10<sup>-</sup><sup>7</sup>), a membranous nephropathy-associated variant at HLA-DQA1 was also associated with CKD attributed to systemic lupus erythematosus (p = 5.9 × 10<sup>-</sup><sup>6</sup>), and an IgA risk variant at HLA-DRB1 was associated with both CKD attributed to granulomatosis with polyangiitis (p = 2.0 × 10<sup>-4</sup>) and to type 1 diabetes (p = 4.6 × 10<sup>-11</sup>). 29066732 2017
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE We also confirm that genetic susceptibility to T1D is associated with the DRB1*03:01-DQA1*05:01-DQB1*02:01 and DRB1*04-DQA1*03:01-DQB1*03:02 haplotypes in Brazilian northeast region. 26492519 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Moreover, the relatives with DRB1*15:01-DQA1*01:02-DQB1*06:02 less frequently expressed autoantibodies associated with higher T1D risk, were less likely to have multiple autoantibodies at baseline, and rarely converted from single to multiple autoantibody positivity on follow-up. 26822082 2016
Diabetes Mellitus, Insulin-Dependent
0.500 PosttranslationalModification disease BEFREE Our aim was to investigate DNA methylation of HLA-DQA1 promoter alleles (QAP) and correlate methylation status with individual HLA-DQA1 allele expression of patients with T1D and healthy controls. 26854762 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The strongly associated T1D haplotype DRB1*0301-DQA1*05-DQB1*0201 is also associated with LADA but confers only half of the T1D risk (odds ratio 2.65 vs 4.84). 26866570 2016
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE High levels of significance were obtained to support higher T1D risk when harbouring DQA1*03:01. 26095634 2015
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Our results showed significant association of 10 single nucleotide polymorphisms (SNPs) with T1D at p<0.01, including HLA-DQA1/rs9272346, ERBB3/rs2292239, SIRPG/rs2281808, IL2-KIAA1109/rs4505848, GLIS3/rs7020673, CD226/rs763361, PTPN2/rs478582, IKZF1/rs10272724, BACH2/rs11755527, C6orf173/rs9388489, whereas 5 more SNPs showed their association at 0.01<p<0.05 in Pakistani population. 25661663 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease CTD_human Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. 26168013 2015
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Susceptibility to type 1 diabetes (T1D) is strongly associated with MHC class II molecules, particularly HLA-DQ8 (DQ8: DQA1*03:01/DQB1*03:02). 25405480 2014
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Among the various haplotypes tested, the DQA1*0201:DQB1*020101G, DQA1*050101:DQB1*020101G, and DQA1*0201:DQB1*030101G were the most frequently found in T1DM patients. 23121162 2013
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Blood samples from 2,433 children newly diagnosed with type 1 diabetes were analysed for TPOAb and TGAb in addition to autoantibodies against arginine zinc transporter 8 (ZnT8RA), tryptophan zinc transporter 8 (ZnT8WA), glutamine zinc transporter 8 (ZnT8QA), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), HLA-DQA-B1 genotypes, thyroid-stimulating hormone (TSH) and free thyroxine (T4). 23666211 2013
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE Notably, the African-specific "DR3" haplotype DRB1*03:02-DQA1*04:01-DQB1*04:02 is protective for type 1 diabetes, in contrast to the common and highly-susceptible DR3 DRB1*03:01-DQA1*05:01-DQB1*02:01. 23801574 2013
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE The present study found a significant SNP rs7990 of HLA-DQA1 (p = 0.009) negative correlation, again indicating that risk from HLA is considerably more with T1DM. 23441825 2013
Diabetes Mellitus, Insulin-Dependent
0.500 GeneticVariation disease BEFREE Owing to strong linkage disequilibrium between markers, pinpointing disease associations within genetic regions is difficult in European ancestral populations, most notably the very strong association of the HLA-DRB1*03-DQA1*05:01-DQB1*02:01 haplotype with Type 1 diabetes risk, which is assumed to be because of a combination of HLA-DRB1 and HLA-DQB1. 23398374 2013
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The notable difference was the identification of DRB1*16-DQA1*0102-DQB1*0501 as a protective haplotype and the absence of a negative association of DRB1*1301-DQA1*0103-DRB1*0603 with T1D. 22583516 2013
Diabetes Mellitus, Insulin-Dependent
0.500 Biomarker disease BEFREE The type 1 diabetes high-risk HLA-DQ A1*05:01-B1*02:01/A1*03:01-B1*03:02 genotype along with lower risk DQ genotypes were determined at the time of clinical onset by PCR and hybridization with allele-specific probes. 21712811 2012