|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12 in Individuals of European Ancestry.
|
26316170 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The minor allele G and its homozygous genotype GG of HLA-DRB1/HLA-DQA1 rs9271366 significantly increased the SLE susceptibility in Malaysian patients, including those of Malay and Chinese ethnicity (odds ratio (OR) > 1, p < 0.05).
|
23257407 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found that 14 SNPs, which were significantly associated with SLE in previous studies, have cis-regulation effects on four eQTL genes (HLA-DQA1, HLA-DQB1, HLA-DQB2, and IRF5) that were also differentially expressed in SLE-related cell groups.
|
23341919 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results from conditional analysis and model choice with the use of the Bayesian information criterion show that the best model for SLE association includes both classical loci (HLA-DRB1(∗)03:01, HLA-DRB1(∗)08:01, and HLA-DQA1(∗)01:02) and two SNPs, rs8192591 (in class III and upstream of NOTCH4) and rs2246618 (MICB in class I).
|
23084292 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, the established SLE-associated HLA-DRB1*15 signal was refined to an interval encompassing HLA-DRB1 and HLA-DQA1.
|
22233601 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
|
21408207 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
|
21408207 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
|
18204098 |
2008 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
When analysis was limited to male subjects with SLE-associated HLA genes (encoding HLA-DR2 or HLA-DR3), the differences further increased for DRB1 basic groups (OR 7.2, P = 0.01), DRB1 alleles (OR 15.0, P = 0.018), DQA1 6.4 (P = 0.006), and DQB1 (OR 5.7, P = 0.027).
|
16142706 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Allele distribution comparison showed in the SLE group a significant increase of HLA-DQA1*0102, DQB1*0402, and DRB1*15; whereas alleles HLA-DQB1*0303 and *0501 were significantly decreased.
|
15603875 |
2004 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To analyse the influence of HLA-DR, DQ and corresponding DQA1 and DQB1 promoter alleles (QAP and QBP) on the anti-Ro alone autoantibody response in systemic lupus erythematosus (SLE).
|
11934968 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the DRB1*0301 is the principal class II allele associated with the genetic susceptibility to SLE in Mexican patients and that the presence of a specific haplotype of the homologous chromosome in patients with DRB1*0407-DQA1*03-DQB1*0302 and DRB1*1501-DQA1*0102-DQB1*0602 haplotypes could have an additive effect on the susceptibility to the disease.
|
11476905 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found a strong association of the DQA1*0102 (p corr = 0.032, rr = 3.39), DQB1*0501 (p corr = 0.003, rr = 4.55), *0601 (p corr = 0.006, rr = 4.22) and DPB1* 0901(p corr = 0.02, rr = 4.58) with SLE.
|
11699726 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*0301 and DQA1*0501 in RA.
|
11436868 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This explains the lack of association with the allele alone, and the evident strong association of SLE with the [HLA-DR3-DQA1*0501-DQB1*0201] and [HLA-DR1-DQA1*0101-DQB1*0501] haplotypes.
|
9808402 |
1998 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
Total SLE group: the frequency of HLA-DR3 and HLA-DQA1*0501 is significantly increased in this group (pc < 0.005, delta = 0.34 and pc < 0.005, delta = 0.45, respectively) although the highest delta value (delta = 0.87) is obtained when the TAP2*01 alleles are considered.
|
9709177 |
1998 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results support the hypothesis that susceptibility to SLE is influenced by several genes with differing functions: HLA-DQA*0501 may predispose to autoantibody formation while C4A*Q0 impairs immune complex clearance.
|
7728395 |
1995 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
This may suggest that HLA class II molecules themselves and/or an unknown susceptibility gene located near the DQA1 and DRB1 loci are involved in the pathogenesis of SLE.
|
7481564 |
1995 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the DQA1*0501-associated 4.56 kb DQA TaqI fragment and the DRB3*01/03-associated 9.79 kb TaqI fragment were also found to be significantly increased in SLE patients (70.8% vs 29.7%; RR = 5.8, p < 10(-2) for the DQA fragment and 70.8% vs 36.1%; RR = 4.3, p < 0.05 for the DRB3 fragment).
|
7912858 |
1994 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We concluded that the presence of antibodies against recombinant U1-nRNP proteins was not significantly associated with any HLA DRB1, DQA1 and DQB1 allele in our group of SLE patients.
|
7824837 |
1994 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By investigating the DQA1 promoter region in the SLE patients we have detected nine different QAP variants.
|
8406614 |
1993 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
While patients with anti-RNP precipitin showed an increased frequency of the DQw8-associated allele DQB1*0302 (P = 0.02, OR = 3.7) compared with normal controls, as well as an increased frequency of the DQw5-associated alleles DQA1*0101 and DQB1*0501 (P = 0.05, OR = 4.2) compared with lupus patients without anti-Sm or RNP.
|
7678744 |
1993 |